Originalauszug anzeigen · cc by
To verify the efficacy of short-term prophylaxis for vaginal or cesarean section childbirth with plasma-derived C1-inhibitor concentrate in pregnant women. They should have hereditary angioedema (HAE) and normal plasma C1-inhibitor. Case report of pregnant women diagnosed with HAE with normal C1-inhibitor who had been treated with intravenous C1-inhibitor concentrate for prophylaxis of angioedema attacks when hospitalized for delivery. The exon 9 of the Factor 12 (F12) genotyping gene was performed by automatic sequencing in all patients. Three cases of pregnant women with HAE with normal serum level of C1-inhibitor are reported. The genetic test detected the presence of a pathogenic mutation in the F12 gene. Deliveries occurred uneventfully and patients had no HAE symptoms in the following 72 hours. C1-inhibitor concentrate could be useful to prevent angioedema attacks during and after delivery.
Auszug in der Originalsprache. Moraes CGFB, Mikami LR, Ferrari LP, Pesquero JB, Chong-Neto HJ, Rosario Filho NA. · Lizenz: cc by. Für den vollständigen Kontext die Originalpublikation öffnen.
Herkunft und Zuordnung
FindZebra
Datensatz: hae:33348403
Quellenstand: f262dbc3a1d234f500d9173f9ebf8d19996b03ba