St. John’s Wort / amitriptyline · source safety mention

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St. John’s Wort · HOS-368716 → amitriptyline · HOS-085911

For most adults who are not taking any kind of medicine, St. John’s wort appears to be safe when used for up to 12 weeks, and some studies indicate that it can be used safely for a year or more. If taken orally in large doses or applied to the skin, St. John’s wort might cause severe skin reactions after sun exposure. Other side effects can include diarrhea, dizziness, trouble sleeping, restlessness, and skin tingling. If you take any type of medicine, talk with your health care provider before using St. John’s wort or other herbal products; some herbs and medicines interact in harmful ways. For example, St. John’s wort can weaken the effects of many medicines, including crucially important medicines such as: Some antidepressants, including amitriptyline and bupropion Birth control pills Cyclosporine, which prevents the body from rejecting transplanted organs Some drugs used to prevent seizures, including phenytoin and carbamazepine Some heart medications, including digoxin and ivabradine Some HIV drugs, including indinavir and nevirapine Some cancer medications, including irinotecan, imatinib, and docetaxel Warfarin, an anticoagulant (blood thinner) Certain statins, including simvastatin In addition, taking St. John’s wort with certain antidepressants or other drugs that affect serotonin (a substance produced by some nerve cells) may lead to increased serotonin-related side effects, which can be serious. It may be unsafe to use St. John’s wort during pregnancy because it may increase the risk of birth defects. Breastfeeding infants of mothers who take St. John’s wort can experience colic, drowsiness, and lethargy.

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