Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 871 Präparate · 48256 Quellenpassagen · 124 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Gegenanzeigen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.3 · PDF-Seite 4
HOS-086138 · Präparat HOS-083284
Concomitant medicinal product levels increased or decreased
1-Adrenoreceptor Alfuzosin Increased plasma concentrations of alfuzosin
Antagonist which may lead to severe hypotension (see
section 4.5).
Analgesics Pethidine, Increased plasma concentrations of
propoxyphene norpethidine and propoxyphene. Thereby,
increasing the risk of serious respiratory
depression or haematologic abnormalities, or
other serious adverse effects from these agents.
Antianginal Ranolazine Increased plasma concentrations of ranolazine
which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Anticancer Neratinib Increased plasma concentrations of neratinib
which may increase the potential for serious
and/or life-threatening reactions including
hepatotoxicity (see section 4.5).
Venetoclax Increased plasma concentrations of venetoclax.
Increased risk of tumor lysis syndrome at the
dose initiation and during the dose-titration
phase (see section 4.5).
Antiarrhythmics Amiodarone, bepridil, Increased plasma concentrations of amiodarone,
dronedarone, bepridil, dronedarone, encainide, flecanide,
encainide, flecanide, propafenone, quinidine. Thereby, increasing the
propafenone, quinidine risk of arrhythmias or other serious adverse
reactions from these agents.
Antibiotic Fusidic Acid Increased plasma concentrations of fusidic acid
and ritonavir.
Anti-gout Colchicine Potential for serious and/or life-threatening
reactions in patients with renal and/or hepatic
impairment (see sections 4.4 and 4.5).
Antihistamines Astemizole, Increased plasma concentrations of astemizole
terfenadine and terfenadine. Thereby, increasing the risk of
serious arrhythmias from these agents.
Antipsychotics/ Lurasidone Increased plasma concentrations of lurasidone
Neuroleptics which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Clozapine, pimozide Increased plasma concentrations of clozapine
and pimozide. Thereby, increasing the risk of
serious haematologic abnormalities, or other
serious adverse effects from these agents.
Quetiapine Increased plasma concentrations of quetiapine
which may lead to coma. The concomitant
administration with quetiapine is
contraindicated (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): encainide (HOS-086145) propafenone (HOS-084530) quinidine (HOS-085593) fusidic acid (HOS-086146) colchicine (HOS-086147) astemizole (HOS-085608) terfenadine (HOS-085607) lurasidone (HOS-086148) clozapine (HOS-086149) pimozide (HOS-085600) quetiapine (HOS-086150) bepridil (HOS-085612) dronedarone (HOS-086144) alfuzosin (HOS-086139) lead (HOS-085592) propoxyphene (HOS-086140) ranolazine (HOS-086141) neratinib (HOS-086142) venetoclax (HOS-086143) amiodarone (HOS-085596)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage f9fe97979894eedcce9660008265f9fc818cdb3984974bb2555b6c5e5869e4e5 · Zeichen 902–5292 im Abschnitt
Gegenanzeigen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 35–36
HOS-086388 · Präparat HOS-083284
35
Analgesics Pethidine, Increased plasma concentrations of
propoxyphene norpethidine and propoxyphene. Thereby,
increasing the risk of serious respiratory
depression or haematologic abnormalities, or
other serious adverse effects from these agents.
Antianginal Ranolazine Increased plasma concentrations of ranolazine
which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Anticancer Neratinib Increased plasma concentrations of neratinib
which may increase the potential for serious
and/or life-threatening reactions including
hepatotoxicity (see section 4.5).
Venetoclax Increased plasma concentrations of venetoclax.
Increased risk of tumor lysis syndrome at the
dose initiation and during the dose-titration
phase (see section 4.5).
Antiarrhythmics Amiodarone, bepridil, Increased plasma concentrations of amiodarone,
dronedarone, bepridil, dronedarone, encainide, flecainide,
encainide, flecainide, propafenone, quinidine. Thereby, increasing
propafenone, quinidine the risk of arrhythmias or other serious adverse
effects from these agents.
Antibiotic Fusidic Acid Increased plasma concentrations of fusidic acid
and ritonavir.
Antihistamines Astemizole, Increased plasma concentrations of astemizole
terfenadine and terfenadine. Thereby, increasing the risk of
serious arrhythmias from these agents.
Anti-gout Colchicine Potential for serious and/or life-threatening
reactions in patients with renal and/or hepatic
impairment (see sections 4.4 and 4.5).
Antipsychotics/ Lurasidone Increased plasma concentrations of lurasidone
Neuroleptics which may increase the potential for serious
and/or life-threatening reactions (see section
4.5).
Clozapine, pimozide Increased plasma concentrations of clozapine
and pimozide. Thereby, increasing the risk of
serious haematologic abnormalities, or other
serious adverse effects from these agents.
Quetiapine Increased plasma concentrations of quetiapine
which may lead to coma. The concomitant
administration with quetiapine is
contraindicated (see section 4.5).
Ergot Derivatives Dihydroergotamine, Increased plasma concentrations of ergot
ergonovine, derivatives leading to acute ergot toxicity,
ergotamine, including vasospasm and ischaemia.
methylergonovine
GI motility agent Cisapride Increased plasma concentrations of cisapride.
Thereby, increasing the risk of serious
arrhythmias from this agent.
Lipid-modifying agents
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lead (HOS-085592) dihydroergotamine (HOS-086152) ergonovine (HOS-086153) ergotamine (HOS-086154) methylergonovine (HOS-086155) cisapride (HOS-085610) quinidine (HOS-085593) fusidic acid (HOS-086146) astemizole (HOS-085608) terfenadine (HOS-085607) colchicine (HOS-086147) lurasidone (HOS-086148) clozapine (HOS-086149) pimozide (HOS-085600) quetiapine (HOS-086150) propoxyphene (HOS-086140) ranolazine (HOS-086141) neratinib (HOS-086142) venetoclax (HOS-086143) amiodarone (HOS-085596) bepridil (HOS-085612) dronedarone (HOS-086144) encainide (HOS-086145) flecainide (HOS-086203) propafenone (HOS-084530)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage f76b82bf2af9e33f5778d35af3ff4a8ea2ea8d392666af7950204db67ec4ac88 · Zeichen 1234–5743 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.5 · PDF-Seite 13
HOS-086202 · Präparat HOS-083284
Antiarrthymics
Amiodarone, bepridil, dronedarone, Ritonavir co-administration is likely to result in increased plasma concentrations of
encainide, flecainide, propafenone, amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, and
quinidine quinidine and is therefore contraindicated (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): amiodarone (HOS-085596) bepridil (HOS-085612) dronedarone (HOS-086144) encainide (HOS-086145) flecainide (HOS-086203) propafenone (HOS-084530) quinidine (HOS-085593)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage db989a5b246ebda2c8effcb5a867688ba67111b2e2655b4b99403e29644def39 · Zeichen 13636–13987 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 45
HOS-086412 · Präparat HOS-083284
Antiarrthymics
Amiodarone, bepridil, dronedarone, Ritonavir co-administration is likely to result in increased plasma concentrations of
encainide, flecainide, propafenone, amiodarone, bepridil, dronedarone, encainide, flecainide, propafenone, and quinidine and
quinidine is therefore contraindicated (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): amiodarone (HOS-085596) bepridil (HOS-085612) dronedarone (HOS-086144) encainide (HOS-086145) flecainide (HOS-086203) propafenone (HOS-084530) quinidine (HOS-085593)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 7be5a56d7eb28c6b0b362a7de5830a5d2ee65bd16f89e27afb151c7f671bb104 · Zeichen 13898–14249 im Abschnitt
Gegenanzeigen · Aptivus
Aptivus 250 mg soft capsules · Abschnitt 4.3 · PDF-Seite 4
HOS-114797 · Präparat HOS-094169
Co-administration of Aptivus with low dose ritonavir, with active substances that are highly dependent
on CYP3A for clearance, and for which elevated plasma concentrations are associated with serious
and/or life-threatening events. These active substances include antiarrhythmics (such as amiodarone,
bepridil, quinidine), antihistamines (such as astemizole, terfenadine), ergot derivatives (such as
dihydroergotamine, ergonovine, ergotamine, methylergonovine), gastrointestinal motility agents (such
as cisapride), antipsychotics (such as pimozide, sertindole, quetiapine, lurasidone), sedatives/hypnotics
(such as orally administered midazolam and triazolam) and HMG-CoA reductase inhibitors (such as
simvastatin and lovastatin) (see section 4.5). Also the use of the alpha-1 adrenoceptor antagonist
alfuzosin, and sildenafil when used for the treatment of pulmonary arterial hypertension. In addition,
co-administration of Aptivus with low dose ritonavir, and medicinal products that are highly
dependent on CYP2D6 for clearance, such as the antiarrhythmics flecainide, propafenone and
metoprolol given in heart failure (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) lurasidone (HOS-086148) midazolam (HOS-086167) triazolam (HOS-086168) simvastatin (HOS-086158) lovastatin (HOS-086157) alfuzosin (HOS-086139) sildenafil (HOS-086162) flecainide (HOS-086203) propafenone (HOS-084530) metoprolol (HOS-090094) pimozide (HOS-085600) sertindole (HOS-085601) ritonavir (HOS-084521) amiodarone (HOS-085596) bepridil (HOS-085612) quinidine (HOS-085593) astemizole (HOS-085608) terfenadine (HOS-085607) dihydroergotamine (HOS-086152) ergonovine (HOS-086153) ergotamine (HOS-086154) methylergonovine (HOS-086155) cisapride (HOS-085610)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-04-23T09:35:00Z · SHA-256 1c396190f98e89933229f2261b0e436bd43dac9c1de8e2dacaa36a755dc06dce · Passage 899ebcf3829943bae5ad39416161803c04f5d7f21f78b5a86a8cc0fb492896e8 · Zeichen 519–1660 im Abschnitt
Wechselwirkungen · Aptivus
Aptivus 250 mg soft capsules · Abschnitt 4.5 · PDF-Seite 19–20
HOS-114844 · Präparat HOS-094169
19
H2-receptor antagonists
No interaction study No data are available for An increase in gastric pH that
performed H2-receptor antagonists in may result from H2-receptor
combination with tipranavir and antagonist therapy is not expected
low dose ritonavir. to have an impact on tipranavir
plasma concentrations.
Antiarrhythmics
Amiodarone Based on theoretical The concomitant use of Aptivus,
Bepridil considerations, tipranavir, co- co-administered with low dose
Quinidine administered with low dose ritonavir, with amiodarone,
No interaction study ritonavir, is expected to increase bepridil or quinidine is
performed amiodarone, bepridil and contraindicated due to potential
quinidine concentrations. serious and/or life threatening
events (see section 4.3)
Inhibition of CYP 3A4 by
tipranavir/r
Flecainide Based on theoretical The concomitant use of Aptivus,
Propafenone considerations, tipranavir, co- co-administered with low dose
Metoprolol (given in heart administered with low dose ritonavir, with flecainide,
failure) ritonavir, is expected to increase propafenone or metoprolol is
No interaction study flecainide, propafenone and contraindicated (see section 4.3)
performed metoprolol concentrations.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) amiodarone (HOS-085596) bepridil (HOS-085612) quinidine (HOS-085593) flecainide (HOS-086203) propafenone (HOS-084530) metoprolol (HOS-090094)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-04-23T09:35:00Z · SHA-256 1c396190f98e89933229f2261b0e436bd43dac9c1de8e2dacaa36a755dc06dce · Passage 6aa9e00d4b58261863af53d4fabbddef6456a645d8623cbe7ba0ff2c874fe543 · Zeichen 48623–50469 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 100 mg/ml oral suspension · Abschnitt 4.5 · PDF-Seite 10
HOS-116324 · Präparat HOS-094447
A clinical study utilising a cocktail of medicinal products that are metabolised by cytochromes
CYP2C9, CYP2C19 and CYP2D6 demonstrated an increase in CYP2C9 and CYP2C19 activity and
inhibition of CYP2D6 activity in the presence of darunavir/ritonavir, which may be attributed to the
presence of low dose ritonavir. Co-administration of darunavir and ritonavir with medicinal products
which are primarily metabolised by CYP2D6 (such as flecainide, propafenone, metoprolol) may result
in increased plasma concentrations of these medicinal products, which could increase or prolong their
therapeutic effect and adverse reactions. Co-administration of darunavir and ritonavir with medicinal
products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone)
may result in decreased systemic exposure to such medicinal products, which could decrease or
shorten their therapeutic effect.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) flecainide (HOS-086203) propafenone (HOS-084530) metoprolol (HOS-090094) warfarin (HOS-085950) methadone (HOS-086198)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 1c69c1e904c5e45f21197cc74aaf3793a744795efd05ba12ed65d139c93b2ca1 · Zeichen 3809–4716 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 100 mg/ml oral suspension · Abschnitt 4.5 · PDF-Seite 14–15
HOS-116357 · Präparat HOS-094447
14
HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir†
Lopinavir/ritonavir lopinavir AUC ↑ 9% Due to a decrease in the exposure
400/100 mg twice daily lopinavir Cmin ↑ 23% (AUC) of darunavir by 40%,
lopinavir Cmax ↓ 2% appropriate doses of the
darunavir AUC ↓ 38% ‡ combination have not been
darunavir Cmin ↓ 51% ‡ established. Hence, concomitant
‡ use of boosted PREZISTA and the
darunavir Cmax ↓ 21%
Lopinavir/ritonavir combination product
lopinavir AUC ↔
533/133.3 mg twice daily lopinavir/ritonavir is
lopinavir Cmin ↑ 13% contraindicated (see section 4.3).
lopinavir Cmax ↑ 11%
darunavir AUC ↓ 41%
darunavir Cmin ↓ 55%
darunavir Cmax ↓ 21%
‡
based upon non dose normalised values
CCR5 ANTAGONIST
Maraviroc maraviroc AUC ↑ 305% The maraviroc dose should be
150 mg twice dailymaraviroc Cmin ND 150 mg twice daily when
maraviroc Cmax ↑ 129% co-administered with boosted
darunavir, ritonavir concentrations were PREZISTA.
consistent with historical data
α1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Based on theoretical considerations Co-administration of boosted
PREZISTA is expected to increase PREZISTA and alfuzosin is
alfuzosin plasma concentrations. contraindicated (see section 4.3).
(CYP3A inhibition)
ANAESTHETIC
Alfentanil Not studied. The metabolism of alfentanil The concomitant use with boosted
is mediated via CYP3A, and may as such PREZISTA may require to lower
be inhibited by boosted PREZISTA. the dose of alfentanil and requires
monitoring for risks of prolonged
or delayed respiratory depression.
ANTIANGINA/ANTIARRHYTHMIC
Disopyramide Not studied. Boosted PREZISTA is Caution is warranted and
Flecainide expected to increase these antiarrhythmic therapeutic concentration
Lidocaine (systemic) plasma concentrations. monitoring, if available, is
Mexiletine (CYP3A and/or CYP2D6 inhibition) recommended for these
Propafenone antiarrhythmics when
co-administered with boosted
PREZISTA.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): propafenone (HOS-084530) protease (HOS-085623) ritonavir (HOS-084521) lopinavir (HOS-086269) maraviroc (HOS-086186) alfuzosin (HOS-086139) alfentanil (HOS-109375) disopyramide (HOS-085595) flecainide (HOS-086203) lidocaine (HOS-108866) mexiletine (HOS-086341)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 79aee1bbebf74d1fc7eeb1f64d47f744ae971edc2caad3984bd946f3f467a703 · Zeichen 24118–27577 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 52
HOS-116503 · Präparat HOS-094447
A clinical study utilising a cocktail of medicinal products that are metabolised by cytochromes
CYP2C9, CYP2C19 and CYP2D6 demonstrated an increase in CYP2C9 and CYP2C19 activity and
inhibition of CYP2D6 activity in the presence of darunavir/ritonavir, which may be attributed to the
presence of low dose ritonavir. Co-administration of darunavir and ritonavir with medicinal products
which are primarily metabolised by CYP2D6 (such as flecainide, propafenone, metoprolol) may result
in increased plasma concentrations of these medicinal products, which could increase or prolong their
therapeutic effect and adverse reactions. Co-administration of darunavir and ritonavir with medicinal
products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone)
may result in decreased systemic exposure to such medicinal products, which could decrease or
shorten their therapeutic effect.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) flecainide (HOS-086203) propafenone (HOS-084530) metoprolol (HOS-090094) warfarin (HOS-085950) methadone (HOS-086198)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 1c69c1e904c5e45f21197cc74aaf3793a744795efd05ba12ed65d139c93b2ca1 · Zeichen 1418–2325 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 56–57
HOS-116516 · Präparat HOS-094447
56
ANTIANGINA/ANTIARRHYTHMIC
Disopyramide Not studied. PREZISTA is expected to Caution is warranted and
Flecainide increase these antiarrhythmic plasma therapeutic concentration
Lidocaine (systemic) concentrations. monitoring, if available, is
Mexiletine (CYP3A and/or CYP2D6 inhibition) recommended for these
Propafenone antiarrhythmics when
co-administered with PREZISTA
with low dose ritonavir.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): disopyramide (HOS-085595) flecainide (HOS-086203) lidocaine (HOS-108866) mexiletine (HOS-086341) propafenone (HOS-084530) ritonavir (HOS-084521)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 57e505293229728296e7dd8480ad0507531ed8d1e94d1f9e07e41fe182a75b64 · Zeichen 20406–21075 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 400 mg film-coated tablets PREZISTA 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 92
HOS-116591 · Präparat HOS-094447
A clinical study utilising a cocktail of medicinal products that are metabolised by cytochromes
CYP2C9, CYP2C19 and CYP2D6 demonstrated an increase in CYP2C9 and CYP2C19 activity and
inhibition of CYP2D6 activity in the presence of darunavir/ritonavir, which may be attributed to the
presence of low dose ritonavir. Co-administration of darunavir and ritonavir with medicinal products
which are primarily metabolised by CYP2D6 (such as flecainide, propafenone, metoprolol) may result
in increased plasma concentrations of these medicinal products, which could increase or prolong their
therapeutic effect and adverse reactions. Co-administration of darunavir and ritonavir with medicinal
products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone)
may result in decreased systemic exposure to such medicinal products, which could decrease or
shorten their therapeutic effect.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) flecainide (HOS-086203) propafenone (HOS-084530) metoprolol (HOS-090094) warfarin (HOS-085950) methadone (HOS-086198)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 1c69c1e904c5e45f21197cc74aaf3793a744795efd05ba12ed65d139c93b2ca1 · Zeichen 3807–4714 im Abschnitt
Wechselwirkungen · Intelence
INTELENCE 25 mg tablets INTELENCE 100 mg tablets INTELENCE 200 mg tablets · Abschnitt 4.5 · PDF-Seite 9–10
HOS-119738 · Präparat HOS-095005
9
Integrase Strand Transfer Inhibitors
Dolutegravir dolutegravir Etravirine significantly
50 mg once daily AUC ↓ 0.29 (0.26-0.34) reduced plasma
Cmin ↓ 0.12 (0.09-0.16) concentrations of
Cmax ↓ 0.48 (0.43-0.54) dolutegravir. The effect of
etravirine etravirine on dolutegravir
AUC ↔a plasma concentrations was
Cmin ↔a mitigated by
Cmax ↔a co-administration of
darunavir/ritonavir or
Dolutegravir + dolutegravir lopinavir/ritonavir, and is
darunavir/ritonavir AUC↓ 0.75 (0.69-0.81) expected to be mitigated by
50 mg once daily + Cmin ↓ 0.63 (0.52-0.77) atazanavir/ritonavir.
600/100 mg twice daily Cmax ↓ 0.88 (0.78-1.00)
etravirine INTELENCE should only be
AUC ↔a used with dolutegravir when
Cmin ↔a co-administered with
Cmax ↔a atazanavir/ritonavir,
darunavir/ritonavir, or
Dolutegravir + dolutegravir lopinavir/ritonavir. This
Lopinavir/ritonavir AUC↔ 1.11(1.02-1.20) combination can be used
50 mg once daily + Cmin ↑ 1.28 (1.13-1.45) without dose adjustment.
400/100 mg twice daily Cmax ↔ 1.07 (1.02-1.13)
etravirine
AUC ↔a
Cmin ↔a
Cmax ↔a
Raltegravir raltegravir INTELENCE and raltegravir
400 mg twice daily AUC ↓ 0.90 (0.68-1.18) can be used without dose
Cmin ↓ 0.66 (0.34-1.26) adjustments.
Cmax ↓ 0.89 (0.68-1.15)
etravirine
AUC ↔ 1.10 (1.03-1.16)
Cmin ↔ 1.17 (1.10-1.26)
Cmax ↔ 1.04 (0.97-1.12)
ANTIARRHYTHMICS
Digoxin digoxin INTELENCE and digoxin
0.5 mg single dose AUC ↑ 1.18 (0.90-1.56) can be used without dose
Cmin ND adjustments. It is
Cmax ↑ 1.19 (0.96-1.49) recommended that digoxin
levels be monitored when
digoxin is combined with
INTELENCE.
Amiodarone Not studied. INTELENCE is expected to Caution is warranted and
Bepridil decrease plasma concentrations of these therapeutic concentration
Disopyramide antiarrhythmics. monitoring, if available, is
Flecainide recommended for
Lidocaine (systemic) antiarrhythmics when
Mexiletine co-administered with
Propafenone INTELENCE.
Quinidine
ANTIBIOTICS
Azithromycin Not studied. Based on the biliary elimination INTELENCE and
pathway of azithromycin, no drug interactions azithromycin can be used
are expected between azithromycin and without dose adjustments.
INTELENCE.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): atazanavir (HOS-086180) raltegravir (HOS-086187) digoxin (HOS-086172) amiodarone (HOS-085596) bepridil (HOS-085612) disopyramide (HOS-085595) flecainide (HOS-086203) lidocaine (HOS-108866) mexiletine (HOS-086341) propafenone (HOS-084530) quinidine (HOS-085593) azithromycin (HOS-088112) dolutegravir (HOS-089992) darunavir (HOS-086181) ritonavir (HOS-084521) lopinavir (HOS-086269)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-08-13T16:37:00Z · SHA-256 b6b2c3fd3d600c0f1fd17ddc8f6c1da50bcb8b2181089113d0397c5ec46864c4 · Passage 88eab8e7a4aadd0b0d68eee60d8b6c66c61e5724eefbfde8ea7e2649457e571e · Zeichen 11566–16118 im Abschnitt
Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 75 mg film-coated tablets Darunavir Viatris 150 mg film-coated tablets Darunavir Viatris 300 mg film-coated tablets Darunavir Viatris 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-134464 · Präparat HOS-097580
A clinical study utilising a cocktail of medicinal products that are metabolised by cytochromes
CYP2C9, CYP2C19 and CYP2D6 demonstrated an increase in CYP2C9 and CYP2C19 activity and
inhibition of CYP2D6 activity in the presence of darunavir/ritonavir, which may be attributed to the
presence of low dose ritonavir. Co-administration of darunavir and ritonavir with medicinal products
which are primarily metabolised by CYP2D6 (such as flecainide, propafenone, metoprolol) may result
in increased plasma concentrations of these medicinal products, which could increase or prolong their
therapeutic effect and adverse reactions. Co-administration of darunavir and ritonavir with medicinal
products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone)
may result in decreased systemic exposure to such medicinal products, which could decrease or
shorten their therapeutic effect.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): methadone (HOS-086198) ritonavir (HOS-084521) flecainide (HOS-086203) propafenone (HOS-084530) metoprolol (HOS-090094) warfarin (HOS-085950)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 1c69c1e904c5e45f21197cc74aaf3793a744795efd05ba12ed65d139c93b2ca1 · Zeichen 1476–2383 im Abschnitt
Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 75 mg film-coated tablets Darunavir Viatris 150 mg film-coated tablets Darunavir Viatris 300 mg film-coated tablets Darunavir Viatris 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 12–13
HOS-134488 · Präparat HOS-097580
12
INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS
Medicinal products by Interaction Geometric mean change Recommendations concerning co-
therapeutic areas (%) administration
Alfuzosin Based on theoretical considerations Co-administration of darunavir with
darunavir is expected to increase low dose ritonavir and alfuzosin is
alfuzosin plasma concentrations. contraindicated (see section 4.3).
(CYP3A inhibition)
ANAESTHETIC
Alfentanil Not studied. The metabolism of The concomitant use with darunavir
alfentanil is mediated via CYP3A, and and low dose ritonavir may require
may as such be inhibited by darunavir to lower the dose of alfentanil and
co-administered with low dose requires monitoring for risks of
ritonavir. prolonged or delayed respiratory
depression.
ANTIANGINA/ANTIARRHYTHMIC
Disopyramide Not studied. Darunavir is expected to Caution is warranted and
Flecainide increase these antiarrhythmic plasma therapeutic concentration
Lidocaine concentrations. monitoring, if available, is
(systemic) (CYP3A and/or CYP2D6 inhibition) recommended for these
Mexiletine antiarrhythmics when co-
Propafenone administered with darunavir with
low dose ritonavir.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): alfuzosin (HOS-086139) ritonavir (HOS-084521) alfentanil (HOS-109375) disopyramide (HOS-085595) flecainide (HOS-086203) lidocaine (HOS-108866) mexiletine (HOS-086341) propafenone (HOS-084530)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 9518a303c5be83b8c623da21f0ef8178c9138853ea1049de3dcd627347157795 · Zeichen 19313–21059 im Abschnitt
Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 400 mg film-coated tablets Darunavir Viatris 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 49
HOS-134594 · Präparat HOS-097580
A clinical study utilising a cocktail of medicinal products that are metabolised by cytochromes
CYP2C9, CYP2C19 and CYP2D6 demonstrated an increase in CYP2C9 and CYP2C19 activity and
inhibition of CYP2D6 activity in the presence of darunavir/ritonavir, which may be attributed to the
presence of low dose ritonavir. Co-administration of darunavir and ritonavir with medicinal products
which are primarily metabolised by CYP2D6 (such as flecainide, propafenone, metoprolol) may result
in increased plasma concentrations of these medicinal products, which could increase or prolong their
therapeutic effect and adverse reactions. Co-administration of darunavir and ritonavir with medicinal
products primarily metabolised by CYP2C9 (such as warfarin) and CYP2C19 (such as methadone)
may result in decreased systemic exposure to such medicinal products, which could decrease or
shorten their therapeutic effect.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) flecainide (HOS-086203) propafenone (HOS-084530) metoprolol (HOS-090094) warfarin (HOS-085950) methadone (HOS-086198)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 1c69c1e904c5e45f21197cc74aaf3793a744795efd05ba12ed65d139c93b2ca1 · Zeichen 3812–4719 im Abschnitt
Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 400 mg film-coated tablets Darunavir Viatris 800 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 53–54
HOS-134613 · Präparat HOS-097580
53
INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS
Medicinal products by Interaction Recommendations concerning co-
therapeutic areas Geometric mean change (%) administration
HIV Protease inhibitors (PIs) - with co-administration of low dose ritonavir†
Lopinavir/ritonavir 400/100 lopinavir AUC ↑ 9% Due to a decrease in the exposure
mg twice daily lopinavir Cmin ↑ 23% (AUC) of darunavir by 40%,
lopinavir Cmax ↓ 2% appropriate doses of the combination
have not been established. Hence,
darunavir AUC ↓ 38%‡ concomitant use of boosted darunavir
darunavir Cmin ↓ 51%‡ and the combination product
darunavir Cmax ↓ 21%‡ lopinavir/ritonavir is contraindicated
Lopinavir/ritonavir lopinavir AUC ↔ (see section 4.3).
533/133.3 mg twice daily lopinavir Cmin ↑ 13%
lopinavir Cmax ↑ 11%
darunavir AUC ↓ 41%
darunavir Cmin ↓ 55%
darunavir Cmax ↓ 21%
‡
based upon non dose normalised
values
CCR5 ANTAGONIST
Maraviroc maraviroc AUC ↑ 305% The maraviroc dose should be 150
150 mg twice daily maraviroc Cmin ND mg twice daily when co-administered
maraviroc Cmax ↑ 129% with boosted darunavir.
darunavir, ritonavir concentrations
were consistent with historical data
α1-ADRENORECEPTOR ANTAGONIST
Alfuzosin Based on theoretical considerations Co-administration of boosted
darunavir is expected to increase darunavir and alfuzosin is
alfuzosin plasma concentrations. contraindicated (see section 4.3).
(CYP3A inhibition)
ANAESTHETIC
Alfentanil Not studied. The metabolism of The concomitant use with boosted
alfentanil is mediated via CYP3A, darunavir may require to lower the
and may as such be inhibited by dose of alfentanil and requires
boosted darunavir. monitoring for risks of prolonged or
delayed respiratory depression.
ANTIANGINA/ANTIARRHYTHMIC
Disopyramide Not studied. Boosted darunavir is Caution is warranted and ther apeutic
Flecainide expected to increase these concentration monitoring, if
Lidocaine (systemic) antiarrhythmic plasma available, is recommended for these
Mexiletine concentrations. antiarrhythmics when co-
Propafenone (CYP3A and/or CYP2D6 administered with boosted darunavir.
inhibition)
Amiodarone Bepridil Co-administration of boosted
Dronedarone Ivabradine darunavir and amiodarone, bepridil,
Quinidine Ranolazine dronedarone, ivabradine, quinidine,
or ranolazine is contraindicated (see
section 4.3).
Digoxin digoxin AUC ↑ 61% Given that digoxin has a narrow
0.4 mg single dose digoxin Cmin ND therapeutic index, it is recommended
digoxin Cmax ↑ 29% that the lowest possible dose of
(↑ digoxin from probable inhibition digoxin should initially be prescribed
of P-gp) in case digoxin is given to patients on
boosted darunavir therapy. The
digoxin dose should be carefully
titrated to obtain the desired clinical
effect while assessing the overall
clinical state of the subject.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): protease (HOS-085623) ritonavir (HOS-084521) lopinavir (HOS-086269) maraviroc (HOS-086186) alfuzosin (HOS-086139) alfentanil (HOS-109375) disopyramide (HOS-085595) flecainide (HOS-086203) lidocaine (HOS-108866) mexiletine (HOS-086341) propafenone (HOS-084530) amiodarone (HOS-085596) bepridil (HOS-085612) dronedarone (HOS-086144) ivabradine (HOS-109426) quinidine (HOS-085593) ranolazine (HOS-086141) digoxin (HOS-086172)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 737ba554b4078e65ecf09cd520335cc5df12785cb4f30673452d55d887588655 · Zeichen 22720–27726 im Abschnitt
Wechselwirkungen · Talzenna
Talzenna 0.1 mg hard capsules Talzenna 0.25 mg hard capsules Talzenna 0.35 mg hard capsules Talzenna 0.5 mg hard capsules Talzenna 1 mg hard capsules · Abschnitt 4.5 · PDF-Seite 7
HOS-140563 · Präparat HOS-098546
Concomitant use of strong P-gp inhibitors (including but not limited to amiodarone, carvedilol,
clarithromycin, cobicistat, darunavir, dronedarone, erythromycin, indinavir, itraconazole,
ketoconazole, lapatinib, lopinavir, propafenone, quinidine, ranolazine, ritonavir, saquinavir, telaprevir,
tipranavir, and verapamil) should be avoided. If co-administration with a strong P-gp inhibitor is
unavoidable, the Talzenna dose should be reduced (see section 4.2).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): propafenone (HOS-084530) quinidine (HOS-085593) ranolazine (HOS-086141) ritonavir (HOS-084521) saquinavir (HOS-084522) telaprevir (HOS-090618) tipranavir (HOS-086184) verapamil (HOS-090602) dronedarone (HOS-086144) erythromycin (HOS-084514) indinavir (HOS-084518) itraconazole (HOS-084516) ketoconazole (HOS-084513) lapatinib (HOS-122565) lopinavir (HOS-086269) amiodarone (HOS-085596) carvedilol (HOS-115322) clarithromycin (HOS-084517) cobicistat (HOS-088111) darunavir (HOS-086181)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-07-18T15:15:00Z · SHA-256 ed4d297943838ad90546bb310100bb9880e0b3c9833c452b88d5862d4841e255 · Passage 234ecfeab8722ea5160a874b4a7240829c7b65e708ad9e195210f3f70d12f3a4 · Zeichen 1803–2263 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.