Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 871 Präparate · 48256 Quellenpassagen · 124 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Gegenanzeigen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.3 · PDF-Seite 5
HOS-086159 · Präparat HOS-083284
Microsomal Lomitapide Increased plasma concentrations of lomitapide
triglyceride transfer (see section 4.5).
protein (MTTP)
inhibitor
PDE5 inhibitors Avanafil Increased plasma concentrations of avanafil
(see section 4.4. and 4.5).
Sildenafil Contraindicated when used for the treatment of
pulmonary arterial hypertension (PAH) only.
Increased plasma concentrations of sildenafil.
Thereby, increasing the potential for sildenafil-
associated adverse events (which include
hypotension and syncope). See section 4.4 and
section 4.5 for co-administration of sildenafil in
patients with erectile dysfunction.
Vardenafil Increased plasma concentrations of vardenafil
(see section 4.4. and 4.5).
Sedatives/hypnotics Clorazepate, diazepam, Increased plasma concentrations of clorazepate,
estazolam, flurazepam, diazepam, estazolam, flurazepam, oral
oral midazolam and midazolam and triazolam. Thereby, increasing
triazolam the risk of extreme sedation and respiratory
depression from these agents. (For caution on
parenterally administered midazolam, see
section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lomitapide (HOS-086160) avanafil (HOS-086161) sildenafil (HOS-086162) vardenafil (HOS-086163) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165) flurazepam (HOS-086166) midazolam (HOS-086167) triazolam (HOS-086168)
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Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 08cb4669d26fd4170f47a5f99fcf18bde7e922c35f378d07e3e1c1cab8b82945 · Zeichen 6375–8447 im Abschnitt
Gegenanzeigen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 37
HOS-086390 · Präparat HOS-083284
Microsomal Lomitapide Increased plasma concentrations of lomitapide
triglyceride transfer (see section 4.5).
protein (MTTP)
inhibitor
PDE5 inhibitor Avanafil Increased plasma concentrations of avanafil
(see section 4.4. and 4.5).
Sildenafil Contraindicated when used for the treatment of
pulmonary arterial hypertension (PAH) only.
Increased plasma concentrations of sildenafil.
Thereby, increasing the potential for sildenafil-
associated adverse events (which include
hypotension and syncope). See section 4.4 and
section 4.5 for co-administration of sildenafil in
patients with erectile dysfunction.
Vardenafil Increased plasma concentrations of vardenafil
(see section 4.4. and 4.5).
Sedatives/hypnotics Clorazepate, diazepam, Increased plasma concentrations of clorazepate,
estazolam, flurazepam, diazepam, estazolam, flurazepam, oral
oral midazolam and midazolam and triazolam. Thereby, increasing
triazolam the risk of extreme sedation and respiratory
depression from these agents. (For caution on
parenterally administered midazolam, see
section 4.5.).
Ritonavir medicinal product level decreased
Herbal Preparation St. John’s Wort Herbal preparations containing St John’s wort
(Hypericum perforatum) due to the risk of
decreased plasma concentrations and reduced
clinical effects of ritonavir (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): flurazepam (HOS-086166) midazolam (HOS-086167) triazolam (HOS-086168) lomitapide (HOS-086160) avanafil (HOS-086161) sildenafil (HOS-086162) vardenafil (HOS-086163) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 235db82cd2afd722d3066659d7d625c3a96a3162e89ca0b2b4a6f83e7ca9d95d · Zeichen 6173–8675 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.5 · PDF-Seite 21
HOS-086319 · Präparat HOS-083284
Sedatives/hynoptics
Clorazepate, diazepam, estazolam, Ritonavir co-administration is likely to result in increased plasma concentrations of
flurazepam, oral and parenteral clorazepate, diazepam, estazolam and flurazepam and is therefore contraindicated
midazolam (see section 4.3).
Midazolam is extensively metabolised by CYP3A4. Co-administration with
ritonavir may cause a large increase in the concentration of this benzodiazepine. No
medicinal product interaction study has been performed for the co-administration of
ritonavir with benzodiazepines. Based on data for other CYP3A4 inhibitors, plasma
concentrations of midazolam are expected to be significantly higher when
midazolam is given orally. Therefore, ritonavir should not be co-administered with
orally administered midazolam (see section 4.3), whereas caution should be used
with co-administration of ritonavir and parenteral midazolam. Data from
concomitant use of parenteral midazolam with other protease inhibitors suggest a
possible 3 – 4 fold increase in midazolam plasma levels. If ritonavir is
co-administered with parenteral midazolam, it should be done in an intensive care
unit (ICU) or similar setting which ensures close clinical monitoring and appropriate
medical management in case of respiratory depression and/or prolonged sedation.
Dosage adjustment for midazolam should be considered, especially if more than a
single dose of midazolam is administered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): diazepam (HOS-085904) estazolam (HOS-086165) flurazepam (HOS-086166) midazolam (HOS-086167) protease (HOS-085623) clorazepate (HOS-086164)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage b4a8c845ab5d7e680623aa73248b83ee123be2ef31c29b06379c9aca6376c2f2 · Zeichen 49471–51496 im Abschnitt
Wechselwirkungen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 54
HOS-086482 · Präparat HOS-083284
Sedatives/hypnotics
Clorazepate, diazepam, estazolam, Ritonavir co-administration is likely to result in increased plasma concentrations of
flurazepam, oral and parenteral clorazepate, diazepam, estazolam and flurazepam and is therefore contraindicated (see
midazolam section 4.3).
Midazolam is extensively metabolised by CYP3A4. Co-administration with ritonavir
may cause a large increase in the concentration of this benzodiazepine. No medicinal
product interaction study has been performed for the co-administration of ritonavir with
benzodiazepines. Based on data for other CYP3A4 inhibitors, plasma concentrations of
midazolam are expected to be significantly higher when midazolam is given orally.
Therefore, ritonavir should not be co-administered with orally administered midazolam
(see section 4.3), whereas caution should be used with co-administration of ritonavir and
parenteral midazolam. Data from concomitant use of parenteral midazolam with other
protease inhibitors suggest a possible 3 – 4 fold increase in midazolam plasma levels. If
ritonavir is co-administered with parenteral midazolam, it should be done in an intensive
care unit (ICU) or similar setting which ensures close clinical monitoring and appropriate
medical management in case of respiratory depression and/or prolonged sedation. Dosage
adjustment for midazolam should be considered, especially if more than a single dose of
midazolam is administered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): flurazepam (HOS-086166) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165) midazolam (HOS-086167) protease (HOS-085623)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 26dfc2e9db64eee7e9dde0c580824f02a0381c69ed172fbd97b8c76f279a1e77 · Zeichen 51537–53525 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 65–66
HOS-116532 · Präparat HOS-094447
65
For the treatment of Not studied. Concomitant use of A safe and effective dose of
pulmonary arterial sildenafil or tadalafil for the treatment of sildenafil for the treatment of
hypertension pulmonary arterial hypertension and pulmonary arterial hypertension
Sildenafil darunavir co-administered with low dose co-administered with PREZISTA
Tadalafil ritonavir may increase plasma and low dose ritonavir has not
concentrations of sildenafil or tadalafil. been established. There is an
(CYP3A inhibition) increased potential for
sildenafil-associated adverse
events (including visual
disturbances, hypotension,
prolonged erection and syncope).
Therefore, co-administration of
PREZISTA with low dose
ritonavir and sildenafil when used
for the treatment of pulmonary
arterial hypertension is
contraindicated (see section 4.3).
Co-administration of tadalafil for
the treatment of pulmonary arterial
hypertension with PREZISTA and
low dose ritonavir is not
recommended.
PROTON PUMP INHIBITORS
Omeprazole # PREZISTA co-administered with
darunavir AUC ↔
20 mg once daily #
darunavir Cmin ↔ low dose ritonavir can be
#
darunavir Cmax ↔ co-administered with proton pump
inhibitors without dose
adjustments.
SEDATIVES/HYPNOTICS
Buspirone Not studied. Sedative/hypnotics are Clinical monitoring is
Clorazepate extensively metabolised by CYP3A. recommended when
Diazepam Co-administration with co-administering PREZISTA with
Estazolam PREZISTA/ritonavir may cause a large these sedatives/hypnotics and a
Flurazepam increase in the concentration of these lower dose of the
Midazolam (parenteral) medicines. sedatives/hypnotics should be
Zolpidem considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sildenafil (HOS-086162) tadalafil (HOS-086316) ritonavir (HOS-084521) omeprazole (HOS-085912) buspirone (HOS-086325) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165) flurazepam (HOS-086166) midazolam (HOS-086167) zolpidem (HOS-086327)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage d55e033062b465321f1e7d6496fca1203bde2ceee842c6b87a58cc57f689d470 · Zeichen 63956–67534 im Abschnitt
Wechselwirkungen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 75 mg film-coated tablets Darunavir Viatris 150 mg film-coated tablets Darunavir Viatris 300 mg film-coated tablets Darunavir Viatris 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 21–22
HOS-134522 · Präparat HOS-097580
21
INTERACTIONS AND DOSE RECOMMENDATIONS WITH OTHER MEDICINAL PRODUCTS
Medicinal products by Interaction Geometric mean change Recommendations concerning co-
therapeutic areas (%) administration
For the treatment of Not studied. Concomitant use of A safe and effective dose of
pulmonary arterial sildenafil or tadalafil for the treatment sildenafil for the treatment of
hypertension of pulmonary arterial hypertension and pulmonary arterial hypertension co-
Sildenafil darunavir co-administered with low administered with darunavir and
Tadalafil dose ritonavir may increase plasma low dose ritonavir has not been
concentrations of sildenafil or tadalafil. established. There is an increased
(CYP3A inhibition) potential for sildenafil- associated
adverse events (including visual
disturbances, hypotension,
prolonged erection and syncope).
Therefore, co- administration of
darunavir with low dose ritonavir
and sildenafil when used for the
treatment of pulmonary arterial
hypertension is contraindicated (see
section 4.3). Co-administration of
tadalafil for the treatment of
pulmonary arterial hypertension
with darunavir and low dose
ritonavir is not recommended.
PROTON PUMP INHIBITORS
Omeprazole #
darunavir AUC ↔ Darunavir co-administered with low
20 mg once daily #
darunavir Cmin ↔ dose ritonavir can be co-
#
darunavir Cmax ↔ administered with proton pump
inhibitors without dose adjustments.
SEDATIVES/HYPNOTICS
Buspirone Not studied. Sedative/hypnotics are Clinical monitoring is
Clorazepate extensively metabolised by CYP3A. recommended when co-
Diazepam Co-administration with administering darunavir with these
Estazolam darunavir/ritonavir may cause a large sedatives/hypnotics and a lower
Flurazepam increase in the concentration of these dose of the sedatives/hypnotics
Midazolam medicines. should be considered.
(parenteral)
Zolpidem If parenteral midazolam is co- If parenteral midazolam is co-
administered with darunavir co- administered with darunavir with
administered with low dose ritonavir it low dose ritonavir, it should be
may cause a large increase in the done in an intensive care unit (ICU)
concentration of this benzodiazepine. or similar setting, which ensures
Data from concomitant use of close clinical monitoring and
parenteral midazolam with other appropriate medical management in
protease inhibitors suggest a possible case of respiratory depression
3-4 fold increase in midazolam plasma and/or prolonged sedation. Dose
levels. adjustment for midazolam should be
considered, especially if more than
a single dose of midazolam is
administered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sildenafil (HOS-086162) tadalafil (HOS-086316) ritonavir (HOS-084521) omeprazole (HOS-085912) buspirone (HOS-086325) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165) flurazepam (HOS-086166) midazolam (HOS-086167) zolpidem (HOS-086327) protease (HOS-085623)
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Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 4418dc5e5d870dbdffdec96577360a7846fd09dd38b08120ab6e36d180a150e5 · Zeichen 64193–68705 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.