Wechselwirkungen · Avonex
AVONEX 30 micrograms/0.5 ml solution for injection. · Abschnitt 4.5 · PDF-Seite 5
HOS-085696 · Präparat HOS-083191
Interferons have been reported to reduce the activity of hepatic cytochrome P450-dependent enzymes in humans and animals. The effect of high-dose AVONEX administration on P450-dependent metabolism in monkeys was evaluated and no changes in liver metabolising capabilities were observed. Caution should be exercised when AVONEX is administered in combination with medicinal products that have a narrow therapeutic index and are largely dependent on the hepatic cytochrome P450 system for clearance, e.g. some classes of antiepileptics and antidepressants.
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