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Exakte Wirkstoffkennungen und zitierbare Passagen zu Wechselwirkungen, Gegenanzeigen und Nebenwirkungen.

Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.

RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 1009 Präparate · 54812 Quellenpassagen · 148 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.

Quellenpassagen (14)

Wechselwirkungen · Epivir

Epivir 150 mg film-coated tablets Epivir 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 6

HOS-085834 · Präparat HOS-083204

The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when the main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim. Other medicinal products (e.g. ranitidine, cimetidine) are eliminated only in part by this mechanism and were shown not to interact with lamivudine. The nucleoside analogues (e.g. didanosine) like zidovudine, are not eliminated by this mechanism and are unlikely to interact with lamivudine.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): trimethoprim (HOS-085184) cimetidine (HOS-085835) didanosine (HOS-085836) zidovudine (HOS-085837) ranitidine (HOS-085660)

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Version 2026-08-20T14:36:00Z · SHA-256 dda482a8b09324ebc742f0589dd9c287ef99dfaee8f30a2889bc848f23ef2100 · Passage f95f33741513a03415ee49d3475d877bb6b9081af94776eebfc6141682077199 · Zeichen 851–1387 im Abschnitt

Wechselwirkungen · Epivir

Epivir 10 mg/mL oral solution · Abschnitt 4.5 · PDF-Seite 21

HOS-085872 · Präparat HOS-083204

The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when the main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim. Other medicinal products (e.g. ranitidine, cimetidine) are eliminated only in part by this mechanism and were shown not to interact with lamivudine. The nucleoside analogues (e.g. didanosine) like zidovudine, are not eliminated by this mechanism and are unlikely to interact with lamivudine.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): trimethoprim (HOS-085184) cimetidine (HOS-085835) didanosine (HOS-085836) zidovudine (HOS-085837) ranitidine (HOS-085660)

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Version 2026-08-20T14:36:00Z · SHA-256 dda482a8b09324ebc742f0589dd9c287ef99dfaee8f30a2889bc848f23ef2100 · Passage f95f33741513a03415ee49d3475d877bb6b9081af94776eebfc6141682077199 · Zeichen 851–1387 im Abschnitt

Wechselwirkungen · Combivir

Combivir 150 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7–8

HOS-088514 · Präparat HOS-083663

7 sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (PCP) and toxoplasmosis have not been studied and should be avoided. ANTIFUNGALS Fluconazole/Lamivudine Interaction not studied. As only limited data are Fluconazole/Zidovudine Zidovudine AUC 74% available the clinical (400 mg once daily/200 mg significance is not known. thrice daily) (UGT inhibition) Monitor for signs of zidovudine toxicity (see section 4.8). ANTIMYCOBACTERIALS Rifampicin/Lamivudine Interaction not studied. Insufficient data to Rifampicin/Zidovudine (600 Zidovudine AUC 48% recommend dosage mg once daily/200 mg thrice adjustment. daily) (UGT induction) ANTICONVULSANTS Phenobarbital/Lamivudine Interaction not studied. Insufficient data to Phenobarbital/Zidovudine Interaction not studied. recommend dosage adjustment. Potential to slightly decrease zidovudine plasma concentrations through UGT induction. Phenytoin/Lamivudine Interaction not studied. Monitor phenytoin Phenytoin/Zidovudine Phenytoin AUC  concentrations. Valproic acid/Lamivudine Interaction not studied. As only limited data are Valproic acid/Zidovudine Zidovudine AUC 80% available the clinical (250 mg or 500 mg thrice significance is not known. daily/100 mg thrice daily) (UGT inhibition) Monitor for signs of zidovudine toxicity (see section 4.8). ANTIHISTAMINES (HISTAMINE H1 RECEPTOR ANTAGONISTS) Ranitidine/Lamivudine Interaction not studied. No dosage adjustment necessary. Clinically significant interaction unlikely. Ranitidine eliminated only in part by renal organic cation transport system. Ranitidine/Zidovudine Interaction not studied Cimetidine/Lamivudine Interaction not studied. No dosage adjustment necessary. Clinically significant interaction unlikely. Cimetidine eliminated only in part by renal organic cation transport system. Cimetidine/Zidovudine Interaction not studied. CYTOTOXICS Cladribine/Lamivudine Interaction not studied Therefore the concomitant use of lamivudine with cladribine In vitro lamivudine inhibits the is not recommended intracellular phosphorylation of (see section 4.4) cladribine leading to a potential risk of cladribine loss of

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sulfamethoxazole (HOS-084533) phenobarbital (HOS-085617) valproic acid (HOS-088515) cimetidine (HOS-085835) histamine (HOS-088516) fluconazole (HOS-087945) ranitidine (HOS-085660) phenytoin (HOS-084531) cladribine (HOS-085842)

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Version 2022-08-29T01:24:00Z · SHA-256 4660d55c0813c2571a95614bba44492fff03e6854bbe956eb43509fe476e679d · Passage 80bfcdbc676c074809992c973802a382b624f4a50bfeaaede637578173acc0cf · Zeichen 3740–7470 im Abschnitt

Wechselwirkungen · Zeffix

Zeffix 100 mg film-coated tablets. · Abschnitt 4.5 · PDF-Seite 6

HOS-089935 · Präparat HOS-083949

Lamivudine is predominantly eliminated by active organic cationic secretion. The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when their main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim. Other medicinal products (e.g. ranitidine, cimetidine) are eliminated only in part by this mechanism and were shown not to interact with lamivudine.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): trimethoprim (HOS-085184) cimetidine (HOS-085835) ranitidine (HOS-085660)

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Version 2026-07-22T15:02:00Z · SHA-256 68d15b158db220a54d54ada9418a4232cc18c7b756744628ac3b16f2fb588c40 · Passage 1675843e9b8449c95d3864ada4cae5935a283fe89e2d5c43d4283e20e5dae000 · Zeichen 221–693 im Abschnitt

Wechselwirkungen · Zeffix

Zeffix 5 mg/ml oral solution. · Abschnitt 4.5 · PDF-Seite 21

HOS-089961 · Präparat HOS-083949

Lamivudine is predominantly eliminated by active organic cationic secretion. The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when their main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim. Other medicinal products (e.g. ranitidine, cimetidine) are eliminated only in part by this mechanism and were shown not to interact with lamivudine.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): trimethoprim (HOS-085184) cimetidine (HOS-085835) ranitidine (HOS-085660)

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Version 2026-07-22T15:02:00Z · SHA-256 68d15b158db220a54d54ada9418a4232cc18c7b756744628ac3b16f2fb588c40 · Passage 1675843e9b8449c95d3864ada4cae5935a283fe89e2d5c43d4283e20e5dae000 · Zeichen 221–693 im Abschnitt

Wechselwirkungen · Trizivir

TRIZIVIR 300 mg/150 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10

HOS-108566 · Präparat HOS-093047

Phenytoin/Abacavir Interaction not studied. Insufficient data to recommend dosage Potential to slightly decrease adjustment. abacavir plasma concentrations through UGT induction. Monitor phenytoin Phenytoin/Lamivudine Interaction not studied. concentrations. Phenytoin/Zidovudine Phenytoin AUC  Valproic acid/Abacavir Interaction not studied. As only limited data are Valproic acid/Lamivudine available the clinical Interaction not studied. Valproic acid/Zidovudine Zidovudine AUC 80%significance is not known. (250 mg or 500 mg thrice Monitor for signs of daily/100 mg thrice daily) (UGT inhibition) zidovudine toxicity (see section 4.8). ANTIHISTAMINES (HISTAMINE H2 RECEPTOR ANTAGONISTS) Ranitidine/Abacavir Interaction not studied. No dosage adjustment Ranitidine/Lamivudine Interaction not studied. necessary.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): valproic acid (HOS-088515) histamine (HOS-088516) ranitidine (HOS-085660) phenytoin (HOS-084531)

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Version 2026-01-19T14:10:00Z · SHA-256 0fa44d429f9cace08dce2fd9d8c4f2ed838fc8cb0ed1b7cfc79bd6b9caa26349 · Passage 409c5f9ee2c015f2b6f723303036c2b2acdd238bc9098136b7a883f2d611ce36 · Zeichen 7108–8354 im Abschnitt

Wechselwirkungen · Trizivir

TRIZIVIR 300 mg/150 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10

HOS-108567 · Präparat HOS-093047

Clinically significant interaction unlikely. Ranitidine eliminated only in part by renal organic cation transport system. Ranitidine/Zidovudine Interaction not studied Cimetidine/Abacavir Interaction not studied. No dosage adjustment Cimetidine/Lamivudine Interaction not studied. necessary.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cimetidine (HOS-085835) ranitidine (HOS-085660)

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Version 2026-01-19T14:10:00Z · SHA-256 0fa44d429f9cace08dce2fd9d8c4f2ed838fc8cb0ed1b7cfc79bd6b9caa26349 · Passage b85b7c4c80673a12dabf6f058474a31a8c27f45c1223b80106f055a5de934f2e · Zeichen 8385–8806 im Abschnitt

Wechselwirkungen · Kivexa

Kivexa 600 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8–9

HOS-113479 · Präparat HOS-093937

8 Drugs by Therapeutic Area Interaction Recommendation concerning Geometric mean change (%) co-administration (Possible mechanism) ANTIHISTAMINES (HISTAMINE H2 RECEPTOR ANTAGONISTS) Ranitidine/Abacavir Interaction not studied. No dosage adjustment Ranitidine/Lamivudine Interaction not studied. necessary.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): histamine (HOS-088516) ranitidine (HOS-085660)

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Version 2026-01-19T12:00:00Z · SHA-256 014b022d5230b58f7efa74f9573b1c2e42d28f6a3d171aa8848bc0f8c92c1380 · Passage 76af9b7107eb9f49ecf3060ff7e00f7229273e610c4dc48278b1e2ac32dd7080 · Zeichen 5254–5649 im Abschnitt

Wechselwirkungen · Kivexa

Kivexa 600 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9

HOS-113480 · Präparat HOS-093937

Clinically significant interaction unlikely. Ranitidine eliminated only in part by renal organic cation transport system. Cimetidine/Abacavir Interaction not studied. No dosage adjustment Cimetidine/Lamivudine Interaction not studied. necessary.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cimetidine (HOS-085835) ranitidine (HOS-085660)

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Version 2026-01-19T12:00:00Z · SHA-256 014b022d5230b58f7efa74f9573b1c2e42d28f6a3d171aa8848bc0f8c92c1380 · Passage 51ae66b7588a773e217ffd1653b0b46a62bdb8ab67abbb21993a7d0c1205a174 · Zeichen 5685–6082 im Abschnitt

Wechselwirkungen · Lamivudine Teva Pharma B.V.

Lamivudine Teva Pharma B.V. 150 mg film-coated tablets Lamivudine Teva Pharma B.V. 300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 6

HOS-211903 · Präparat HOS-154784

The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when the main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim. Other medicinal products (e.g. ranitidine, cimetidine) are eliminated only in part by this mechanism and were shown not to interact with lamivudine. The nucleoside analogues (e.g. didanosine) like zidovudine, are not eliminated by this mechanism and are unlikely to interact with lamivudine.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): trimethoprim (HOS-085184) cimetidine (HOS-085835) didanosine (HOS-085836) zidovudine (HOS-085837) ranitidine (HOS-085660)

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Version 2023-04-21T15:48:00Z · SHA-256 20f7e52b86e41eb238a7c02628d41f826d204c97eddc200b9de9d5dfd73ec34c · Passage f95f33741513a03415ee49d3475d877bb6b9081af94776eebfc6141682077199 · Zeichen 793–1329 im Abschnitt

Wechselwirkungen · Lamivudine Teva

Lamivudine Teva 100 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 6

HOS-211991 · Präparat HOS-154800

Lamivudine is predominantly eliminated by active organic cationic secretion. The possibility of interactions with other medicinal products administered concurrently should be considered, particularly when their main route of elimination is active renal secretion via the organic cationic transport system e.g. trimethoprim. Other medicinal products (e.g. ranitidine, cimetidine) are eliminated only in part by this mechanism and were shown not to interact with lamivudine.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): trimethoprim (HOS-085184) cimetidine (HOS-085835) ranitidine (HOS-085660)

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Version 2024-06-07T02:00:00Z · SHA-256 7ebfd130ef9d9ca18166e2a55526570d39c018726558f43f8bad673f541d0883 · Passage 1675843e9b8449c95d3864ada4cae5935a283fe89e2d5c43d4283e20e5dae000 · Zeichen 221–693 im Abschnitt

Wechselwirkungen · Triumeq

Triumeq 50 mg/600 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 11–12

HOS-129263 · Präparat HOS-096703

11 Antimycobacterials Rifampicin/Dolutegravir Dolutegravir ↓ The dose of dolutegravir is 50 mg twice AUC ↓ 54% daily when co-administered with Cmax ↓ 43% rifampicin. As Triumeq is a fixed dose Cτ ↓ 72% tablet, an additional 50 mg tablet of (induction of UGT1A1 dolutegravir should be administered, and CYP3A enzymes) approximately 12 hours after Triumeq for the duration of the rifampicin co- administration (a separate preparation of dolutegravir is available for this dose adjustment, see section 4.2). Rifabutin Dolutegravir ↔ No dose adjustment is necessary. AUC ↓ 5% Cmax ↑ 16% Cτ ↓ 30% (induction of UGT1A1 and CYP3A enzymes) Anticonvulsants Carbamazepine/Dolutegravir Dolutegravir ↓ The recommended dose of dolutegravir AUC ↓ 49% is 50 mg twice daily when co- Cmax ↓ 33% administered with carbamazepine. As Cτ ↓ 73% Triumeq is a fixed dose tablet, an additional 50 mg tablet of dolutegravir should be administered, approximately 12 hours after Triumeq for the duration of the carbamazepine co-administration (a separate preparation of dolutegravir is available for this dose adjustment, see section 4.2). Phenobarbital/Dolutegravir Dolutegravir↓ The recommended dose of dolutegravir Phenytoin/Dolutegravir (Not studied, decrease is 50 mg twice daily when co- Oxcarbazepine/Dolutegravir expected due to induction administered with these metabolic of UGT1A1 and CYP3A inducers. As Triumeq is a fixed dose enzymes, a similar tablet, an additional 50 mg tablet of reduction in exposure as dolutegravir should be administered, observed with approximately 12 hours after Triumeq carbamazepine is for the duration of the co-administration expected) with these metabolic inducers (a separate preparation of dolutegravir is available for this dose adjustment, see section 4.2). Antihistamines (histamine H2 receptor antagonists) Ranitidine Interaction not studied. No dose adjustment necessary.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) carbamazepine (HOS-085618) rifabutin (HOS-086262) histamine (HOS-088516) ranitidine (HOS-085660) oxcarbazepine (HOS-110224) phenytoin (HOS-084531)

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Version 2026-06-15T14:46:00Z · SHA-256 b49ac3bee235cd6ac4023cc2bbeb8b80e01234448e4e420209ba281a1edf7209 · Passage c667a478669bd5d7bf1481bff4152a60605199708e7c92778db166c77cf6e33c · Zeichen 16252–19999 im Abschnitt

Wechselwirkungen · Triumeq

Triumeq 5 mg/60 mg/30 mg dispersible tablets · Abschnitt 4.5 · PDF-Seite 49

HOS-129358 · Präparat HOS-096703

Phenobarbital/Dolutegravir Dolutegravir↓ The recommended dose of dolutegravir Phenytoin/Dolutegravir (Not studied, decrease should be adjusted when co- Oxcarbazepine/Dolutegravir expected due to induction administered with these metabolic of UGT1A1 and CYP3A inducers. enzymes, a similar reduction in exposure as Dosing recommendations are provided observed with in Table 2 (see section 4.2) carbamazepine is expected) Antihistamines (histamine H2 receptor antagonists) Ranitidine Interaction not studied. No dose adjustment necessary.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) carbamazepine (HOS-085618) histamine (HOS-088516) ranitidine (HOS-085660) oxcarbazepine (HOS-110224) phenytoin (HOS-084531)

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Version 2026-06-15T14:46:00Z · SHA-256 b49ac3bee235cd6ac4023cc2bbeb8b80e01234448e4e420209ba281a1edf7209 · Passage 377acffb9770a7db982e8e184dd5622d08989e157d6cb396dd8e98806885ed5e · Zeichen 15553–16394 im Abschnitt

Wechselwirkungen · Dovato

Dovato 50 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10

HOS-142836 · Präparat HOS-098886

(organic cation transporter inhibition) Antimycobacterials Rifampicin/Dolutegravir Dolutegravir  The recommended dose of dolutegravir AUC  54% is 50 mg twice daily when Cmax  43% co-administered with rifampicin. As C  72% Dovato is a fixed-dose tablet, an (induction of UGT1A1 additional 50 mg tablet of dolutegravir and CYP3A enzymes) should be administered, approximately 12 hours after Dovato for the duration of the rifampicin co-administration (a separate formulation of dolutegravir is available for this dose adjustment, see section 4.2). Rifabutin/Dolutegravir Dolutegravir  No dose adjustment is necessary. AUC  5% Cmax  16% Cτ  30% (induction of UGT1A1 and CYP3A enzymes) Anticonvulsants Carbamazepine/Dolutegravir Dolutegravir  The recommended dose of dolutegravir AUC  49% is 50 mg twice daily when Cmax  33% co-administered with these metabolic C  73% inducers. As Dovato is a fixed-dose tablet, an additional 50 mg tablet of Phenobarbital/Dolutegravir Dolutegravir  dolutegravir should be administered, Phenytoin/Dolutegravir (Not studied, decrease approximately 12 hours after Dovato for Oxcarbazepine/Dolutegravir expected due to induction the duration of the co-administration of UGT1A1 and CYP3A with these metabolic inducers (a separate enzymes, a similar formulation of dolutegravir is available reduction in exposure as for this dose adjustment, see section observed with 4.2). carbamazepine is expected). Antihistamines (histamine H2 receptor antagonists) Ranitidine Interaction not studied. No dosage adjustment necessary.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) carbamazepine (HOS-085618) rifabutin (HOS-086262) histamine (HOS-088516) ranitidine (HOS-085660) oxcarbazepine (HOS-110224) phenytoin (HOS-084531)

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Version 2025-11-14T01:22:00Z · SHA-256 9ebb38c4be2b7abc7ba2934afb44e75aa1d6b86e46ecc069e568b333119de792 · Passage 3b246ec15edb1d0208dd215632db834aa0dd314859cdad3106476a513fa6340a · Zeichen 15431–18327 im Abschnitt

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