Ein Paarvergleich findet Originalpassagen, die den anderen Wirkstoff wörtlich nennen. Aussagen gelten für das jeweilige Präparat und seine Formulierung. Klassenbegriffe und abweichende Synonyme können fehlen. Kein Treffer bedeutet nicht, dass keine Wechselwirkung besteht.
RxNorm 05-Oct-2026 · geprüft 2026-10-25 · 871 Präparate · 48256 Quellenpassagen · 124 strukturierte Aussagen. Automatisch aktualisiert, ohne menschliche Freigabe.
Gegenanzeigen · Norvir
Norvir 100 mg powder for oral suspension · Abschnitt 4.3 · PDF-Seite 5
HOS-086159 · Präparat HOS-083284
Microsomal Lomitapide Increased plasma concentrations of lomitapide
triglyceride transfer (see section 4.5).
protein (MTTP)
inhibitor
PDE5 inhibitors Avanafil Increased plasma concentrations of avanafil
(see section 4.4. and 4.5).
Sildenafil Contraindicated when used for the treatment of
pulmonary arterial hypertension (PAH) only.
Increased plasma concentrations of sildenafil.
Thereby, increasing the potential for sildenafil-
associated adverse events (which include
hypotension and syncope). See section 4.4 and
section 4.5 for co-administration of sildenafil in
patients with erectile dysfunction.
Vardenafil Increased plasma concentrations of vardenafil
(see section 4.4. and 4.5).
Sedatives/hypnotics Clorazepate, diazepam, Increased plasma concentrations of clorazepate,
estazolam, flurazepam, diazepam, estazolam, flurazepam, oral
oral midazolam and midazolam and triazolam. Thereby, increasing
triazolam the risk of extreme sedation and respiratory
depression from these agents. (For caution on
parenterally administered midazolam, see
section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lomitapide (HOS-086160) avanafil (HOS-086161) sildenafil (HOS-086162) vardenafil (HOS-086163) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165) flurazepam (HOS-086166) midazolam (HOS-086167) triazolam (HOS-086168)
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Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 08cb4669d26fd4170f47a5f99fcf18bde7e922c35f378d07e3e1c1cab8b82945 · Zeichen 6375–8447 im Abschnitt
Gegenanzeigen · Norvir
Norvir 100 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 37
HOS-086390 · Präparat HOS-083284
Microsomal Lomitapide Increased plasma concentrations of lomitapide
triglyceride transfer (see section 4.5).
protein (MTTP)
inhibitor
PDE5 inhibitor Avanafil Increased plasma concentrations of avanafil
(see section 4.4. and 4.5).
Sildenafil Contraindicated when used for the treatment of
pulmonary arterial hypertension (PAH) only.
Increased plasma concentrations of sildenafil.
Thereby, increasing the potential for sildenafil-
associated adverse events (which include
hypotension and syncope). See section 4.4 and
section 4.5 for co-administration of sildenafil in
patients with erectile dysfunction.
Vardenafil Increased plasma concentrations of vardenafil
(see section 4.4. and 4.5).
Sedatives/hypnotics Clorazepate, diazepam, Increased plasma concentrations of clorazepate,
estazolam, flurazepam, diazepam, estazolam, flurazepam, oral
oral midazolam and midazolam and triazolam. Thereby, increasing
triazolam the risk of extreme sedation and respiratory
depression from these agents. (For caution on
parenterally administered midazolam, see
section 4.5.).
Ritonavir medicinal product level decreased
Herbal Preparation St. John’s Wort Herbal preparations containing St John’s wort
(Hypericum perforatum) due to the risk of
decreased plasma concentrations and reduced
clinical effects of ritonavir (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): flurazepam (HOS-086166) midazolam (HOS-086167) triazolam (HOS-086168) lomitapide (HOS-086160) avanafil (HOS-086161) sildenafil (HOS-086162) vardenafil (HOS-086163) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165)
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Version 2025-11-11T18:35:00Z · SHA-256 82413695e61cf39577e85c47e382ee60197570a4ae72fe81d6e24e4211cd2d43 · Passage 235db82cd2afd722d3066659d7d625c3a96a3162e89ca0b2b4a6f83e7ca9d95d · Zeichen 6173–8675 im Abschnitt
Gegenanzeigen · Kaletra
Kaletra (80 mg + 20 mg) / ml oral solution · Abschnitt 4.3 · PDF-Seite 6
HOS-108817 · Präparat HOS-093083
HMG Co-A Reductase Lovastatin, simvastatin Increased plasma concentrations of
Inhibitors lovastatin and simvastatin; thereby,
increasing the risk of myopathy
including rhabdomyolysis (see section
4.5).
Microsomal Lomitapide Increased plasma concentrations of
triglyceride transfer lomitapide (see section 4.5).
protein (MTTP)
inhibitor
Phosphodiesterase Avanafil Increased plasma concentrations of
(PDE5) inhibitors avanafil (see sections 4.4 and 4.5).
Sildenafil Contraindicated when used for the
treatment of pulmonary arterial
hypertension (PAH) only. Increased
plasma concentrations of sildenafil.
Thereby, increasing the potential for
sildenafil-associated adverse events
(which include hypotension and
syncope). See section 4.4 and section
4.5 for co-administration of sildenafil in
patients with erectile dysfunction.
Vardenafil Increased plasma concentrations of
vardenafil (see sections 4.4 and 4.5)
Sedatives/hypnotics Oral midazolam, triazolam Increased plasma concentrations of oral
midazolam and triazolam. Thereby,
increasing the risk of extreme sedation
and respiratory depression from these
agents.
For caution on parenterally administered
midazolam, see section 4.5.
Lopinavir/ritonavir medicinal product level decreased
Herbal products St. John’s wort Herbal preparations containing St John’s
wort (Hypericum perforatum) due to the
risk of decreased plasma concentrations
and reduced clinical effects of lopinavir
and ritonavir (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lovastatin (HOS-086157) simvastatin (HOS-086158) lomitapide (HOS-086160) avanafil (HOS-086161) sildenafil (HOS-086162) vardenafil (HOS-086163) midazolam (HOS-086167) triazolam (HOS-086168)
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Version 2025-12-02T16:00:00Z · SHA-256 441d9e5f9e4b42d645e4bd802abc892cef6574b0be5b3f18d2a96678774ae365 · Passage c938be9b188cbabde88400ddb49de67c2831b955f638dc8fa5306b13f1652968 · Zeichen 6187–9289 im Abschnitt
Gegenanzeigen · Kaletra
Kaletra 100 mg/25 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 78–79
HOS-109064 · Präparat HOS-093083
78
Phosphodiesterase Avanafil Increased plasma concentrations of
(PDE5) inhibitors avanafil (see sections 4.4 and 4.5)
Sildenafil Contraindicated when used for the
treatment of pulmonary arterial
hypertension (PAH) only. Increased
plasma concentrations of sildenafil.
Thereby, increasing the potential for
sildenafil-associated adverse events
(which include hypotension and syncope).
See section 4.4 and section 4.5 for
co-administration of sildenafil in patients
with erectile dysfunction.
Vardenafil Increased plasma concentrations of
vardenafil (see sections 4.4 and 4.5)
Sedatives/hypnotics Oral midazolam, triazolam Increased plasma concentrations of oral
midazolam and triazolam. Thereby,
increasing the risk of extreme sedation
and respiratory depression from these
agents.
For caution on parenterally administered
midazolam, see section 4.5.
Lopinavir/ritonavir medicinal product level decreased
Herbal products St. John’s wort Herbal preparations containing St John’s
wort (Hypericum perforatum) due to the
risk of decreased plasma concentrations
and reduced clinical effects of lopinavir
and ritonavir (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): avanafil (HOS-086161) sildenafil (HOS-086162) vardenafil (HOS-086163) midazolam (HOS-086167) triazolam (HOS-086168)
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Wechselwirkungen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 24
HOS-112118 · Präparat HOS-093615
The mechanism of interaction is CYP3A4
and UGT1A1 inhibition.
Concentrations of atazanavir (when given
with ritonavir) were not significantly
affected.
Methadone, stable maintenance No significant effect on methadone No dosage adjustment is necessary
dose concentrations was observed. Given that if methadone is co-administered
(atazanavir 400 mg once daily) low dose ritonavir (100 mg twice daily) with REYATAZ.
has been shown to have no significant
effect on methadone concentrations, no
interaction is expected if methadone is co-
administered with REYATAZ, based on
these data.
PULMONARY ARTERIAL HYPERTENSION
PDE5 Inhibitors
Sildenafil Co-administration with REYATAZ may A safe and effective dose in
result in increased concentrations of the combination with REYATAZ has
PDE5 inhibitor and an increase in PDE5- not been established for sildenafil
inhibitor-associated adverse events. when used to treat pulmonary
arterial hypertension. Sildenafil,
The mechanism of interaction is CYP3A4 when used for the treatment of
inhibition by atazanavir and/or ritonavir. pulmonary arterial hypertension, is
contraindicated (see section 4.3).
SEDATIVES
Benzodiazepines
Midazolam Midazolam and triazolam are extensively Co-administration of REYATAZ
Triazolam metabolised by CYP3A4. Co- with triazolam or orally
administration with REYATAZ may cause administered midazolam is
a large increase in the concentration of contraindicated (see section 4.3),
these benzodiazepines. No drug interaction whereas caution should be used
study has been performed for the co- with co-administration of
administration of REYATAZ with REYATAZ and parenteral
benzodiazepines. Based on data for other midazolam. If REYATAZ is co-
CYP3A4 inhibitors, plasma concentrations administered with parenteral
of midazolam are expected to be midazolam, it should be done in an
significantly higher when midazolam is intensive care unit (ICU) or similar
given orally. Data from concomitant use of setting which ensures close clinical
parenteral midazolam with other protease monitoring and appropriate medical
inhibitors suggest a possible 3-4-fold management in case of respiratory
increase in midazolam plasma levels. depression and/or prolonged
sedation. Dosage adjustment for
midazolam should be considered,
especially if more than a single
dose of midazolam is administered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) methadone (HOS-086198) sildenafil (HOS-086162) midazolam (HOS-086167) triazolam (HOS-086168) protease (HOS-085623)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
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Gegenanzeigen · Aptivus
Aptivus 250 mg soft capsules · Abschnitt 4.3 · PDF-Seite 4
HOS-114797 · Präparat HOS-094169
Co-administration of Aptivus with low dose ritonavir, with active substances that are highly dependent
on CYP3A for clearance, and for which elevated plasma concentrations are associated with serious
and/or life-threatening events. These active substances include antiarrhythmics (such as amiodarone,
bepridil, quinidine), antihistamines (such as astemizole, terfenadine), ergot derivatives (such as
dihydroergotamine, ergonovine, ergotamine, methylergonovine), gastrointestinal motility agents (such
as cisapride), antipsychotics (such as pimozide, sertindole, quetiapine, lurasidone), sedatives/hypnotics
(such as orally administered midazolam and triazolam) and HMG-CoA reductase inhibitors (such as
simvastatin and lovastatin) (see section 4.5). Also the use of the alpha-1 adrenoceptor antagonist
alfuzosin, and sildenafil when used for the treatment of pulmonary arterial hypertension. In addition,
co-administration of Aptivus with low dose ritonavir, and medicinal products that are highly
dependent on CYP2D6 for clearance, such as the antiarrhythmics flecainide, propafenone and
metoprolol given in heart failure (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): quetiapine (HOS-086150) lurasidone (HOS-086148) midazolam (HOS-086167) triazolam (HOS-086168) simvastatin (HOS-086158) lovastatin (HOS-086157) alfuzosin (HOS-086139) sildenafil (HOS-086162) flecainide (HOS-086203) propafenone (HOS-084530) metoprolol (HOS-090094) pimozide (HOS-085600) sertindole (HOS-085601) ritonavir (HOS-084521) amiodarone (HOS-085596) bepridil (HOS-085612) quinidine (HOS-085593) astemizole (HOS-085608) terfenadine (HOS-085607) dihydroergotamine (HOS-086152) ergonovine (HOS-086153) ergotamine (HOS-086154) methylergonovine (HOS-086155) cisapride (HOS-085610)
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Gegenanzeigen · Prezista
PREZISTA 100 mg/ml oral suspension · Abschnitt 4.3 · PDF-Seite 6
HOS-116288 · Präparat HOS-094447
Darunavir boosted with either ritonavir or cobicistat inhibits the elimination of active substances that
are highly dependent on CYP3A for clearance, which results in increased exposure to the
co-administered medicinal product. Therefore, concomitant treatment with such medicinal products
for which elevated plasma concentrations are associated with serious and/or life-threatening events is
contraindicated (applies to darunavir boosted with either ritonavir or cobicistat). These active
substances include e.g.:
- alfuzosin
- amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine
- astemizole, terfenadine
- colchicine when used in patients with renal and/or hepatic impairment (see section 4.5)
- ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine)
- elbasvir/grazoprevir
- cisapride
- dapoxetine
- domperidone
- naloxegol
- lurasidone, pimozide, quetiapine, sertindole (see section 4.5)
- triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
see section 4.5)
- sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil
- simvastatin, lovastatin, lomitapide (see section 4.5)
- ticagrelor (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ranolazine (HOS-086141) astemizole (HOS-085608) terfenadine (HOS-085607) colchicine (HOS-086147) dihydroergotamine (HOS-086152) ergotamine (HOS-086154) methylergonovine (HOS-086155) elbasvir (HOS-108814) grazoprevir (HOS-108815) cisapride (HOS-085610) domperidone (HOS-114656) naloxegol (HOS-109428) lurasidone (HOS-086148) pimozide (HOS-085600) quetiapine (HOS-086150) sertindole (HOS-085601) triazolam (HOS-086168) midazolam (HOS-086167) sildenafil (HOS-086162) avanafil (HOS-086161) simvastatin (HOS-086158) lovastatin (HOS-086157) lomitapide (HOS-086160) ticagrelor (HOS-112065) ritonavir (HOS-084521) cobicistat (HOS-088111) alfuzosin (HOS-086139) amiodarone (HOS-085596) bepridil (HOS-085612) dronedarone (HOS-086144) ivabradine (HOS-109426) quinidine (HOS-085593)
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Gegenanzeigen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 49
HOS-116497 · Präparat HOS-094447
Co-administration of PREZISTA with low dose ritonavir, with active substances that are highly
dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with
serious and/or life-threatening events. These active substances include e.g.:
- alfuzosin
- amiodarone, bepridil, dronedarone, ivabradine, quinidine, ranolazine
- astemizole, terfenadine
- colchicine when used in patients with renal and/or hepatic impairment (see section 4.5)
- ergot derivatives (e.g. dihydroergotamine, ergometrine, ergotamine, methylergonovine)
- elbasvir/grazoprevir
- cisapride
- dapoxetine
- domperidone
- naloxegol
- lurasidone, pimozide, quetiapine, sertindole (see section 4.5)
- triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
see section 4.5)
- sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil
- simvastatin, lovastatin and lomitapide (see section 4.5)
- ticagrelor (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): astemizole (HOS-085608) terfenadine (HOS-085607) colchicine (HOS-086147) dihydroergotamine (HOS-086152) ergotamine (HOS-086154) methylergonovine (HOS-086155) elbasvir (HOS-108814) quinidine (HOS-085593) ranolazine (HOS-086141) ritonavir (HOS-084521) alfuzosin (HOS-086139) amiodarone (HOS-085596) bepridil (HOS-085612) dronedarone (HOS-086144) ivabradine (HOS-109426) grazoprevir (HOS-108815) cisapride (HOS-085610) domperidone (HOS-114656) naloxegol (HOS-109428) lurasidone (HOS-086148) pimozide (HOS-085600) quetiapine (HOS-086150) sertindole (HOS-085601) triazolam (HOS-086168) midazolam (HOS-086167) sildenafil (HOS-086162) avanafil (HOS-086161) simvastatin (HOS-086158) lovastatin (HOS-086157) lomitapide (HOS-086160) ticagrelor (HOS-112065)
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Gegenanzeigen · Prezista
PREZISTA 400 mg film-coated tablets PREZISTA 800 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 87–88
HOS-116581 · Präparat HOS-094447
87
- dapoxetine
- domperidone
- naloxegol
- lurasidone, pimozide, quetiapine, sertindole (see section 4.5)
- triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
see section 4.5)
- sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil
- simvastatin, lovastatin and lomitapide (see section 4.5)
- ticagrelor (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): domperidone (HOS-114656) naloxegol (HOS-109428) lurasidone (HOS-086148) pimozide (HOS-085600) quetiapine (HOS-086150) sertindole (HOS-085601) triazolam (HOS-086168) midazolam (HOS-086167) sildenafil (HOS-086162) avanafil (HOS-086161) simvastatin (HOS-086158) lovastatin (HOS-086157) lomitapide (HOS-086160) ticagrelor (HOS-112065)
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Wechselwirkungen · Prezista
PREZISTA 100 mg/ml oral suspension · Abschnitt 4.5 · PDF-Seite 23–24
HOS-116425 · Präparat HOS-094447
23
For the treatment of Not studied. Concomitant use of A safe and effective dose of
pulmonary arterial sildenafil or tadalafil for the treatment of sildenafil for the treatment of
hypertension pulmonary arterial hypertension and pulmonary arterial hypertension
Sildenafil boosted PREZISTA may increase plasma co-administered with boosted
Tadalafil concentrations of sildenafil or tadalafil. PREZISTA has not been
(CYP3A inhibition) established. There is an increased
potential for sildenafil-associated
adverse events (including visual
disturbances, hypotension,
prolonged erection and syncope).
Therefore, co-administration of
boosted PREZISTA and sildenafil
when used for the treatment of
pulmonary arterial hypertension is
contraindicated (see section 4.3).
Co-administration of tadalafil for
the treatment of pulmonary arterial
hypertension with boosted
PREZISTA is not recommended.
PROTON PUMP INHIBITORS
Omeprazole # Boosted PREZISTA can be
darunavir AUC ↔
20 mg once daily #
darunavir Cmin ↔ co-administered with proton pump
#
darunavir Cmax ↔ inhibitors without dose
adjustments.
SEDATIVES/HYPNOTICS
Buspirone Not studied. Sedative/hypnotics are Clinical monitoring is
Clorazepate extensively metabolised by CYP3A. recommended when
Diazepam Co-administration with boosted co-administering boosted
Estazolam PREZISTA may cause a large increase in PREZISTA with these
Flurazepam the concentration of these medicines. sedatives/hypnotics and a lower
Midazolam (parenteral) dose of the sedatives/hypnotics
Zolpidem should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sildenafil (HOS-086162) tadalafil (HOS-086316) omeprazole (HOS-085912) buspirone (HOS-086325) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165) flurazepam (HOS-086166) midazolam (HOS-086167) zolpidem (HOS-086327)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage 9634d5188deeb063704d3dec6fa9fde3f4c10970d03131c50c223d1e001e36d7 · Zeichen 72803–75985 im Abschnitt
Wechselwirkungen · Prezista
PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 65–66
HOS-116532 · Präparat HOS-094447
65
For the treatment of Not studied. Concomitant use of A safe and effective dose of
pulmonary arterial sildenafil or tadalafil for the treatment of sildenafil for the treatment of
hypertension pulmonary arterial hypertension and pulmonary arterial hypertension
Sildenafil darunavir co-administered with low dose co-administered with PREZISTA
Tadalafil ritonavir may increase plasma and low dose ritonavir has not
concentrations of sildenafil or tadalafil. been established. There is an
(CYP3A inhibition) increased potential for
sildenafil-associated adverse
events (including visual
disturbances, hypotension,
prolonged erection and syncope).
Therefore, co-administration of
PREZISTA with low dose
ritonavir and sildenafil when used
for the treatment of pulmonary
arterial hypertension is
contraindicated (see section 4.3).
Co-administration of tadalafil for
the treatment of pulmonary arterial
hypertension with PREZISTA and
low dose ritonavir is not
recommended.
PROTON PUMP INHIBITORS
Omeprazole # PREZISTA co-administered with
darunavir AUC ↔
20 mg once daily #
darunavir Cmin ↔ low dose ritonavir can be
#
darunavir Cmax ↔ co-administered with proton pump
inhibitors without dose
adjustments.
SEDATIVES/HYPNOTICS
Buspirone Not studied. Sedative/hypnotics are Clinical monitoring is
Clorazepate extensively metabolised by CYP3A. recommended when
Diazepam Co-administration with co-administering PREZISTA with
Estazolam PREZISTA/ritonavir may cause a large these sedatives/hypnotics and a
Flurazepam increase in the concentration of these lower dose of the
Midazolam (parenteral) medicines. sedatives/hypnotics should be
Zolpidem considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sildenafil (HOS-086162) tadalafil (HOS-086316) ritonavir (HOS-084521) omeprazole (HOS-085912) buspirone (HOS-086325) clorazepate (HOS-086164) diazepam (HOS-085904) estazolam (HOS-086165) flurazepam (HOS-086166) midazolam (HOS-086167) zolpidem (HOS-086327)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-07-26T09:44:00Z · SHA-256 457dafbe8b3b9cee45b9ca7b46919ded598e0d0cd16715525d161e54f80b9117 · Passage d55e033062b465321f1e7d6496fca1203bde2ceee842c6b87a58cc57f689d470 · Zeichen 63956–67534 im Abschnitt
Wechselwirkungen · Daxas
Daxas 250 micrograms tablets · Abschnitt 4.5 · PDF-Seite 5
HOS-122833 · Präparat HOS-095587
No interactions were observed with inhaled salbutamol, formoterol, budesonide and oral montelukast,
digoxin, warfarin, sildenafil and midazolam.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): montelukast (HOS-122836) digoxin (HOS-086172) warfarin (HOS-085950) sildenafil (HOS-086162) midazolam (HOS-086167) formoterol (HOS-122834) budesonide (HOS-086332)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-10-07T12:30:00Z · SHA-256 c9483b9b45da34f36b9555fd877e4e90626a238a341771b848d1c6fda96d3345 · Passage 340b03373dd6c217e4fa5e307a3695f180a5d90ecb8c8685c0ac0b60699472b5 · Zeichen 1864–2008 im Abschnitt
Wechselwirkungen · Daxas
Daxas 500 micrograms film-coated tablets · Abschnitt 4.5 · PDF-Seite 18
HOS-122861 · Präparat HOS-095587
No interactions were observed with inhaled salbutamol, formoterol, budesonide and oral montelukast,
digoxin, warfarin, sildenafil and midazolam.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): budesonide (HOS-086332) montelukast (HOS-122836) digoxin (HOS-086172) warfarin (HOS-085950) formoterol (HOS-122834) sildenafil (HOS-086162) midazolam (HOS-086167)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-10-07T12:30:00Z · SHA-256 c9483b9b45da34f36b9555fd877e4e90626a238a341771b848d1c6fda96d3345 · Passage 340b03373dd6c217e4fa5e307a3695f180a5d90ecb8c8685c0ac0b60699472b5 · Zeichen 1864–2008 im Abschnitt
Wechselwirkungen · Zykadia
Zykadia 150 mg hard capsules · Abschnitt 4.5 · PDF-Seite 8
HOS-131695 · Präparat HOS-097124
Ceritinib has been classified in vivo as a strong CYP3A4 inhibitor and has the potential to interact with
medicinal products that are metabolised by CYP3A, which may lead to increased serum
concentrations of the other product. Co-administration of a single dose of midazolam (a sensitive
CYP3A substrate) following 3 weeks of ceritinib dosing in patients (750 mg daily fasted) increased
the midazolam AUCinf (90% CI) by 5.4-fold (4.6, 6.3) compared to midazolam alone.
Co-administration of ceritinib with substrates primarily metabolised by CYP3A or CYP3A substrates
known to have narrow therapeutic indices (e.g. alfuzosin, amiodarone, cisapride, ciclosporin,
dihydroergotamine, ergotamine, fentanyl, pimozide, quetiapine, quinidine, lovastatin, simvastatin,
sildenafil, midazolam, triazolam, tacrolimus, alfentanil and sirolimus) should be avoided and
alternative medicinal products that are less sensitive to CYP3A4 inhibition should be used if possible.
If unavoidable, dose reduction for co-administered medicinal products that are CYP3A substrates with
narrow therapeutic indices should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lead (HOS-085592) quinidine (HOS-085593) lovastatin (HOS-086157) simvastatin (HOS-086158) midazolam (HOS-086167) alfuzosin (HOS-086139) amiodarone (HOS-085596) cisapride (HOS-085610) dihydroergotamine (HOS-086152) ergotamine (HOS-086154) fentanyl (HOS-086196) pimozide (HOS-085600) quetiapine (HOS-086150) sildenafil (HOS-086162) triazolam (HOS-086168) tacrolimus (HOS-085202) alfentanil (HOS-109375) sirolimus (HOS-085172)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-01-29T12:25:00Z · SHA-256 0b1dbf25bbec546abc5492b7ae4f6a782b99bf34d000b6651bc6bf57cbe85e06 · Passage 8c077815baee1cc86d1631acdc9514aeea609ffa511fd705feb86861d6e3d369 · Zeichen 3957–5064 im Abschnitt
Wechselwirkungen · Zykadia
Zykadia 150 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 34
HOS-131749 · Präparat HOS-097124
Ceritinib has been classified in vivo as a strong CYP3A4 inhibitor and has the potential to interact with
medicinal products that are metabolised by CYP3A, which may lead to increased serum
concentrations of the other product. Co-administration of a single dose of midazolam (a sensitive
CYP3A substrate) following 3 weeks of ceritinib dosing in patients (750 mg daily fasted) increased
the midazolam AUCinf (90% CI) by 5.4-fold (4.6, 6.3) compared to midazolam alone.
Co-administration of ceritinib with substrates primarily metabolised by CYP3A or CYP3A substrates
known to have narrow therapeutic indices (e.g. alfuzosin, amiodarone, cisapride, ciclosporin,
dihydroergotamine, ergotamine, fentanyl, pimozide, quetiapine, quinidine, lovastatin, simvastatin,
sildenafil, midazolam, triazolam, tacrolimus, alfentanil and sirolimus) should be avoided and
alternative medicinal products that are less sensitive to CYP3A4 inhibition should be used if possible.
If unavoidable, dose reduction for co-administered medicinal products that are CYP3A substrates with
narrow therapeutic indices should be considered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lead (HOS-085592) amiodarone (HOS-085596) cisapride (HOS-085610) midazolam (HOS-086167) alfuzosin (HOS-086139) dihydroergotamine (HOS-086152) ergotamine (HOS-086154) fentanyl (HOS-086196) pimozide (HOS-085600) quetiapine (HOS-086150) quinidine (HOS-085593) lovastatin (HOS-086157) simvastatin (HOS-086158) sildenafil (HOS-086162) triazolam (HOS-086168) tacrolimus (HOS-085202) alfentanil (HOS-109375) sirolimus (HOS-085172)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-01-29T12:25:00Z · SHA-256 0b1dbf25bbec546abc5492b7ae4f6a782b99bf34d000b6651bc6bf57cbe85e06 · Passage 8c077815baee1cc86d1631acdc9514aeea609ffa511fd705feb86861d6e3d369 · Zeichen 3957–5064 im Abschnitt
Wechselwirkungen · Zydelig
Zydelig 100 mg film-coated tablets Zydelig 150 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10
HOS-132114 · Präparat HOS-097192
Sildenafil, tadalafil ↑ serum concentrations Particular caution must be used and
dose reduction may be considered
when prescribing sildenafil or tadalafil
with idelalisib with increased
monitoring for adverse events.
SEDATIVES/HYPNOTICS
Midazolam (oral), triazolam ↑ serum concentrations Idelalisib should not be
co-administered with midazolam
(oral) or triazolam.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sildenafil (HOS-086162) tadalafil (HOS-086316) midazolam (HOS-086167) triazolam (HOS-086168)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2024-10-21T17:52:00Z · SHA-256 f55f90ba278a87ef1c8e7162344ed4bd66ac7180deaf4c8fda3eca5bbf8e87e5 · Passage bc3979ff78cbb65b9744e66e451ebc3a2793d76e9f69eb0c7efd3efa776477df · Zeichen 12394–13198 im Abschnitt
Gegenanzeigen · Genvoya
Genvoya 150 mg/150 mg/200 mg/10 mg film-coated tablets Genvoya 90 mg/90 mg/120 mg/6 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 4
HOS-133892 · Präparat HOS-097520
Co-administration with medicinal products that are highly dependent on CYP3A for clearance and for
which elevated plasma concentrations are associated with serious or life-threatening adverse reactions.
Therefore, Genvoya should not be co-administered with medicinal products that include, but are not
limited to, the following (see sections 4.4 and 4.5):
• alpha 1-adrenoreceptor antagonists: alfuzosin
• antiarrhythmics: amiodarone, quinidine
• ergot derivatives: dihydroergotamine, ergometrine, ergotamine
• gastrointestinal motility agents: cisapride
• HMG Co-A reductase inhibitors: lovastatin, simvastatin
• lipid-modifying agent: lomitapide
• neuroleptics/antipsychotics: pimozide, lurasidone
• PDE-5 inhibitors: sildenafil for the treatment of pulmonary arterial hypertension
• sedatives/hypnotics: orally administered midazolam, triazolam
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lurasidone (HOS-086148) sildenafil (HOS-086162) midazolam (HOS-086167) triazolam (HOS-086168) alfuzosin (HOS-086139) amiodarone (HOS-085596) quinidine (HOS-085593) dihydroergotamine (HOS-086152) ergotamine (HOS-086154) cisapride (HOS-085610) lovastatin (HOS-086157) simvastatin (HOS-086158) lomitapide (HOS-086160) pimozide (HOS-085600)
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Version 2022-11-28T16:51:00Z · SHA-256 5b1a306ad5f7dd33700254558ee14691810f4eafdcf9d1256ccc229ad5e01997 · Passage 0f88e646d6d04d22e82ffc09fef77e923a5508a7e7714d22031d9defc05e872d · Zeichen 94–985 im Abschnitt
Wechselwirkungen · Genvoya
Genvoya 150 mg/150 mg/200 mg/10 mg film-coated tablets Genvoya 90 mg/90 mg/120 mg/6 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-133928 · Präparat HOS-097520
Co-administration of Genvoya and some medicinal products that are primarily metabolised by CYP3A
may result in increased plasma concentrations of these products, which are associated with the
potential for serious or life-threatening adverse reactions such as peripheral vasospasm or ischaemia
(e.g., dihydroergotamine, ergotamine, ergometrine), or myopathy, including rhabdomyolysis (e.g.,
simvastatin, lovastatin), or prolonged or increased sedation or respiratory depression (e.g., orally
administered midazolam or triazolam). Co-administration of Genvoya and other medicinal products
primarily metabolised by CYP3A such as amiodarone, lomitapide, quinidine, cisapride, pimozide,
lurasidone, alfuzosin and sildenafil for pulmonary arterial hypertension is contraindicated (see
section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lurasidone (HOS-086148) alfuzosin (HOS-086139) sildenafil (HOS-086162) dihydroergotamine (HOS-086152) ergotamine (HOS-086154) simvastatin (HOS-086158) lovastatin (HOS-086157) midazolam (HOS-086167) triazolam (HOS-086168) amiodarone (HOS-085596) lomitapide (HOS-086160) quinidine (HOS-085593) cisapride (HOS-085610) pimozide (HOS-085600)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2022-11-28T16:51:00Z · SHA-256 5b1a306ad5f7dd33700254558ee14691810f4eafdcf9d1256ccc229ad5e01997 · Passage 4dadcf172c034e4a296aebd72b2538a7bc83a7607f8e8d78e400d88f4a537379 · Zeichen 4154–4947 im Abschnitt
Gegenanzeigen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 75 mg film-coated tablets Darunavir Viatris 150 mg film-coated tablets Darunavir Viatris 300 mg film-coated tablets Darunavir Viatris 600 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 5–6
HOS-134455 · Präparat HOS-097580
5
- triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
see section 4.5)
- sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil
- simvastatin, lovastatin and lomitapide (see section 4.5)
- ticagrelor (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): triazolam (HOS-086168) midazolam (HOS-086167) sildenafil (HOS-086162) avanafil (HOS-086161) simvastatin (HOS-086158) lovastatin (HOS-086157) lomitapide (HOS-086160) ticagrelor (HOS-112065)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 67ccf31dc842ed6550f68f2d93baf91e6520ae446833e0ce19545c6e63675c7e · Zeichen 1247–1563 im Abschnitt
Gegenanzeigen · Darunavir Viatris (previously Darunavir Mylan)
Darunavir Viatris 400 mg film-coated tablets Darunavir Viatris 800 mg film-coated tablets · Abschnitt 4.3 · PDF-Seite 44–45
HOS-134581 · Präparat HOS-097580
44
- cisapride
- dapoxetine
- domperidone
- naloxegol
- lurasidone, pimozide, quetiapine, sertindole (see section 4.5)
- triazolam, midazolam administered orally (for caution on parenterally administered midazolam,
see section 4.5)
- sildenafil - when used for the treatment of pulmonary arterial hypertension, avanafil
- simvastatin, lovastatin and lomitapide (see section 4.5)
- ticagrelor (see section 4.5).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cisapride (HOS-085610) domperidone (HOS-114656) naloxegol (HOS-109428) lurasidone (HOS-086148) pimozide (HOS-085600) quetiapine (HOS-086150) sertindole (HOS-085601) triazolam (HOS-086168) midazolam (HOS-086167) sildenafil (HOS-086162) avanafil (HOS-086161) simvastatin (HOS-086158) lovastatin (HOS-086157) lomitapide (HOS-086160) ticagrelor (HOS-112065)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-10-20T12:32:00Z · SHA-256 50f4771a683f17214737463c6df88a158b1e699bbb9916413602e547e369e804 · Passage 29477591ae9b5ad89ec5266de4b7dbb3559f802d26c18cc2d6b3cb9400a9440c · Zeichen 2288–2741 im Abschnitt
This product uses publicly available data from the U.S. National Library of Medicine (NLM), National Institutes of Health, Department of Health and Human Services; NLM is not responsible for the product and does not endorse or recommend this or any other product.