Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Exelon

Exelon 4.6 mg/24 h transdermal patch Exelon 9.5 mg/24 h transdermal patch Exelon 13.3 mg/24 h transdermal patch · Abschnitt 4.8 · PDF-Seite 41

HOS-087865 · Präparat HOS-083555

Infections and infestations Common Urinary tract infection Metabolism and nutrition disorders Common Anorexia, decreased appetite Uncommon Dehydration Psychiatric disorders Common Anxiety, depression, delirium, agitation Uncommon Aggression Not known Hallucinations, restlessness, nightmares Nervous system disorders Common Headache, syncope, dizziness Uncommon Psychomotor hyperactivity Very rare Extrapyramidal symptoms Not known Worsening of Parkinson’s disease, seizure, tremor, somnolence, pleurothotonus (Pisa syndrome) Cardiac disorders Uncommon Bradycardia Not known Atrioventricular block, atrial fibrillation, tachycardia, sick sinus syndrome Vascular disorders Not known Hypertension Gastrointestinal disorders Common Nausea, vomiting, diarrhoea, dyspepsia, abdominal pain Uncommon Gastric ulcer Not known Pancreatitis Hepatobiliary disorders Not known Hepatitis, elevated liver function tests Skin and subcutaneous tissue disorders Common Rash Not known Pruritus, erythema, urticaria, vesicles, allergic dermatitis (disseminated) Renal and urinary disorders Common Urinary incontinence General disorders and administration site conditions Common Application site skin reactions (e.g. application site erythema*, application site pruritus*, application site oedema*, application site dermatitis, application site irritation), asthenic conditions (e.g. fatigue, asthenia), pyrexia, weight decreased Rare Fall *In a 24-week controlled study in Japanese patients, application site erythema, application site oedema and application site pruritus were reported as “very common”.

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