Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Combivir

Combivir 150 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7–8

HOS-088514 · Präparat HOS-083663

7  sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (PCP) and toxoplasmosis have not been studied and should be avoided. ANTIFUNGALS Fluconazole/Lamivudine Interaction not studied. As only limited data are Fluconazole/Zidovudine Zidovudine AUC 74% available the clinical (400 mg once daily/200 mg significance is not known. thrice daily) (UGT inhibition) Monitor for signs of zidovudine toxicity (see section 4.8). ANTIMYCOBACTERIALS Rifampicin/Lamivudine Interaction not studied. Insufficient data to Rifampicin/Zidovudine (600 Zidovudine AUC 48% recommend dosage mg once daily/200 mg thrice adjustment. daily) (UGT induction) ANTICONVULSANTS Phenobarbital/Lamivudine Interaction not studied. Insufficient data to Phenobarbital/Zidovudine Interaction not studied. recommend dosage adjustment. Potential to slightly decrease zidovudine plasma concentrations through UGT induction. Phenytoin/Lamivudine Interaction not studied. Monitor phenytoin Phenytoin/Zidovudine Phenytoin AUC  concentrations. Valproic acid/Lamivudine Interaction not studied. As only limited data are Valproic acid/Zidovudine Zidovudine AUC 80% available the clinical (250 mg or 500 mg thrice significance is not known. daily/100 mg thrice daily) (UGT inhibition) Monitor for signs of zidovudine toxicity (see section 4.8). ANTIHISTAMINES (HISTAMINE H1 RECEPTOR ANTAGONISTS) Ranitidine/Lamivudine Interaction not studied. No dosage adjustment necessary. Clinically significant interaction unlikely. Ranitidine eliminated only in part by renal organic cation transport system. Ranitidine/Zidovudine Interaction not studied Cimetidine/Lamivudine Interaction not studied. No dosage adjustment necessary. Clinically significant interaction unlikely. Cimetidine eliminated only in part by renal organic cation transport system. Cimetidine/Zidovudine Interaction not studied. CYTOTOXICS Cladribine/Lamivudine Interaction not studied Therefore the concomitant use of lamivudine with cladribine In vitro lamivudine inhibits the is not recommended intracellular phosphorylation of (see section 4.4) cladribine leading to a potential risk of cladribine loss of

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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sulfamethoxazole (HOS-084533) phenobarbital (HOS-085617) valproic acid (HOS-088515) cimetidine (HOS-085835) histamine (HOS-088516) fluconazole (HOS-087945) ranitidine (HOS-085660) phenytoin (HOS-084531) cladribine (HOS-085842)