Wechselwirkungen · Combivir
Combivir 150 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-088518 · Präparat HOS-083663
Methadone dosage adjustment unlikely in majority of patients; occasionally methadone re-titration may be required. URICOSURIC Probenecid/Lamivudine Interaction not studied. As only limited data are Probenecid/Zidovudine Zidovudine AUC 106% available the clinical (500 mg four times significance is not known. daily/2mg/kg thrice daily) (UGT inhibition) Monitor for signs of zidovudine toxicity (see section 4.8). MISCELLANEOUS Sorbitol solution (3.2g , 10.2 g, Single dose lamivudine oral When possible, avoid chronic 13.4 g)/ Lamivudine solution 300 mg coadministration of Combivir with medicinal products Lamivudine: containing sorbitol or other AUC 14%; 32%; 36% osmotic acting poly-alcohols or monosaccharide alcohols Cmax 28%; 52%, 55%. (e.g. xylitol, mannitol, lactitol, maltitol). Consider more frequent monitoring of HIV-1 viral load when chronic coadministration cannot be avoided.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): maltitol (HOS-085849) methadone (HOS-086198) xylitol (HOS-085846) mannitol (HOS-085847) probenecid (HOS-085208) lactitol (HOS-085848) sorbitol (HOS-085845)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2022-08-29T01:24:00Z · SHA-256 4660d55c0813c2571a95614bba44492fff03e6854bbe956eb43509fe476e679d · Passage c60e9a85277b6d563917784e4dc019a6b2a7eb8117d4abdfd711dea58f60eabc · Zeichen 8504–10729 im Abschnitt