Wirkstoffe & Arzneimittelsicherheit

Gegenanzeigen · Metalyse

Metalyse 5 000 units (25 mg) powder for solution for injection · Abschnitt 4.3 · PDF-Seite 16–17

HOS-091194 · Präparat HOS-084225

16 - Acute ischaemic stroke without disabling neurological deficit, or symptoms rapidly improving before start of injection - Any history of central nervous system damage (i.e. neoplasm, aneurysm, intracranial or spinal surgery) - Known haemorrhagic diathesis - Severe uncontrolled arterial hypertension (see section 4.4) - Major surgery, biopsy of a parenchymal organ, or significant trauma within the past 2 months - Recent trauma to the head or cranium - Bacterial endocarditis, pericarditis - Acute pancreatitis - Severe hepatic dysfunction, including hepatic failure, cirrhosis, portal hypertension (oesophageal varices) and active hepatitis - Active ulcerative gastro-intestinal disease - Known arterial aneurysm and/or arterial/venous malformation - Neoplasm with increased bleeding risk - Administration of heparin within the previous 48 hours and a thromboplastin time exceeding the upper limit of normal for laboratory - Patients with any history of prior stroke and concomitant diabetes - Prior stroke within the last 3 months - Platelet count of below 100 000/mm3 - Systolic blood pressure > 185 mmHg or diastolic BP > 110 mmHg, or when BP cannot be reduced below these limits by careful management - Blood glucose < 50 mg/dL (see section 4.4) or > 400 mg/dL (< 2.8 mM or > 22.2 mM)

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): heparin (HOS-086930) glucose (HOS-088412)