Nebenwirkungen · Targretin
Targretin 75 mg soft capsules · Abschnitt 4.8 · PDF-Seite 9
HOS-091548 · Präparat HOS-084349
The majority of adverse reactions were noted at a higher incidence at doses greater than 300 mg/m2/day. Generally, these resolved without sequelae on dose reduction or withdrawal of treatment. However, among a total of 810 patients, including those without malignancy, treated with bexarotene, there were three serious adverse reactions with fatal outcome (acute pancreatitis, subdural haematoma and liver failure). Of these, liver failure, subsequently determined to be not related to bexarotene, was the only one to occur in a CTCL patient.
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Version 2025-08-12T12:14:00Z · SHA-256 3bf4d2f2fd7cbd6812f185953fbdb6223f58862715009080d9c1b2058c9f08b5 · Passage 17bd6ae5c43c6d4c5d09452cab4d9f5ff30e5c7b7188bb05e7331a6e7dc4f4bd · Zeichen 11500–12042 im Abschnitt