Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Trizivir

TRIZIVIR 300 mg/150 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 10–11

HOS-108569 · Präparat HOS-093047

10 Drugs by Therapeutic Interaction Recommendation Area Geometric mean change concerning co- (%) administration (Possible mechanism) CYTOTOXICS Cladribine/Lamivudine Interaction not studied. Therefore, the concomitant use of lamivudine with In vitro lamivudine inhibits the cladribine is not intracellular phosphorylation of recommended (see section cladribine leading to a potential 4.4). risk of cladribine loss of efficacy in case of combination in the clinical setting. Some clinical findings also support a possible interaction between lamivudine and cladribine. OPIOIDS Methadone/Abacavir Abacavir: AUC  As only limited data are (40 to 90 mg once daily for 14 Cmax 35% available the clinical days/600 mg single dose, then significance is not known. 600 mg twice daily for 14 Methadone: CL/F 22% Monitor for signs of days) zidovudine toxicity (see Methadone/Lamivudine Interaction not studied. section 4.8). Methadone/Zidovudine Zidovudine AUC 43% (30 to 90 mg once Methadone AUC  Methadone dosage adjustment daily/200 mg every 4 hours) unlikely in majority of patients; occasionally methadone re-titration may be required. RETINOIDS Retinoid compounds Interaction not studied. Insufficient data to (e.g. isotretinoin)/Abacavir recommend dosage Possible interaction given adjustment. common pathway of elimination via alcohol dehydrogenase. Retinoid compounds Interaction not studied. (e.g. isotretinoin)/Lamivudine No drug interaction studies Retinoid compounds Interaction not studied. (e.g. isotretinoin)/Zidovudine URICOSURIC Probenecid/Abacavir Interaction not studied. As only limited data are Probenecid/Lamivudine Interaction not studied. available the clinical Probenecid/Zidovudine Zidovudine AUC 106% significance is not known. (500 mg four times Monitor for signs of daily/2 mg/kg thrice daily) (UGT inhibition) zidovudine toxicity (see section 4.8). MISCELLANEOUS Ethanol/Abacavir Abacavir: AUC 41% No dosage adjustment (0.7 g/kg single dose/600 mg Ethanol: AUC  necessary. single dose) (Inhibition of alcohol dehydrogenase) Ethanol/Lamivudine Interaction not studied. Ethanol/Zidovudine Interaction not studied.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): methadone (HOS-086198) isotretinoin (HOS-108570) probenecid (HOS-085208) ethanol (HOS-089988) cladribine (HOS-085842)