Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Trizivir

TRIZIVIR 300 mg/150 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 11–12

HOS-108571 · Präparat HOS-093047

11  Sorbitol solution (3.2 g, 10.2 g, Single dose lamivudine oral When possible, avoid chronic 13.4 g)/ Lamivudine solution 300 mg coadministration of Trizivir with medicinal products Lamivudine: containing sorbitol or other AUC  14%; 32%; 36% osmotic acting poly-alcohols or monosaccharide alcohols Cmax  28%; 52%, 55%. (e.g. xylitol, mannitol, lactitol, maltitol). Consider more frequent monitoring of HIV-1 viral load when chronic coadministration cannot be avoided. Riociguat/Abacavir Riociguat  Riociguat dose may need to be reduced. Consult the In vitro, abacavir inhibits riociguat prescribing CYP1A1. Concomitant information for dosing administration of a single dose recommendations. of riociguat (0.5 mg) to HIV patients receiving the combination of abacavir/dolutegravir/lamivudine (600 mg/50 mg/300 mg once daily) led to an approximately three-fold higher riociguat AUC(0-∞) when compared to historical riociguat AUC(0-∞) reported in healthy subjects. Abbreviations:  = Increase; =decrease; = no significant change; AUC=area under the concentration versus time curve; Cmax=maximum observed concentration; CL/F=apparent oral clearance

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): maltitol (HOS-085849) riociguat (HOS-086293) dolutegravir (HOS-089992) xylitol (HOS-085846) mannitol (HOS-085847) lactitol (HOS-085848) sorbitol (HOS-085845)