Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Viread

Viread 123 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9

HOS-110490 · Präparat HOS-093385

Medicinal product by Effects on drug levels Recommendation concerning therapeutic areas Mean percent change in AUC, co-administration with 245 mg (dose in mg) Cmax, Cmin tenofovir disoproxil ANTI-INFECTIVES Antiretrovirals Protease inhibitors Atazanavir/Ritonavir Atazanavir: No dose adjustment is (300 q.d./100 q.d.) AUC: ↓ 25% recommended. The increased Cmax: ↓ 28% exposure of tenofovir could Cmin: ↓ 26% potentiate tenofovir-associated Tenofovir: adverse events, including renal AUC: ↑ 37% disorders. Renal function should Cmax: ↑ 34% be closely monitored Cmin: ↑ 29% (see section 4.4). Lopinavir/Ritonavir Lopinavir/ritonavir: No dose adjustment is (400 b.i.d./100 b.i.d.) No significant effect on recommended. The increased lopinavir/ritonavir PK exposure of tenofovir could parameters. potentiate tenofovir-associated Tenofovir: adverse events, including renal AUC: ↑ 32% disorders. Renal function should Cmax: ↔ be closely monitored Cmin: ↑ 51% (see section 4.4). Darunavir/Ritonavir Darunavir: No dose adjustment is (300/100 b.i.d.) No significant effect on recommended. The increased darunavir/ritonavir PK exposure of tenofovir could parameters. potentiate tenofovir-associated Tenofovir: adverse events, including renal AUC: ↑ 22% disorders. Renal function should Cmin: ↑ 37% be closely monitored (see section 4.4). NRTIs Didanosine Co-administration of tenofovir Co-administration of tenofovir disoproxil and didanosine results disoproxil and didanosine is not in a 40-60% increase in systemic recommended (see section 4.4). exposure to didanosine. Increased systemic exposure to didanosine may increase didanosine related adverse reactions. Rarely, pancreatitis and lactic acidosis, sometimes fatal, have been reported. Co-administration of tenofovir disoproxil and didanosine at a dose of 400 mg daily has been associated with a significant decrease in CD4 cell count, possibly due to an intracellular interaction increasing phosphorylated (i.e. active) didanosine. A decreased dosage of 250 mg didanosine co-administered with tenofovir disoproxil therapy has been associated with reports of high rates of virological failure within several tested combinations for the treatment of HIV-1 infection.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tenofovir (HOS-088083) lopinavir (HOS-086269) atazanavir (HOS-086180) protease (HOS-085623) didanosine (HOS-085836) darunavir (HOS-086181) ritonavir (HOS-084521)