Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Viread

Viread 245 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 132–133

HOS-110780 · Präparat HOS-093385

132  Medicinal product by Effects on drug levels Recommendation therapeutic areas Mean percent change in AUC, Cmax, concerning (dose in mg) Cmin co-administration with 245 mg tenofovir disoproxil Ledipasvir/Sofosbuvir Ledipasvir: Increased plasma (90 mg/400 mg q.d.) + AUC: ↔ concentrations of tenofovir Darunavir/Ritonavir Cmax: ↔ resulting from (800 mg q.d./100 mg q.d.) + Cmin: ↔ co-administration of tenofovir Emtricitabine/Tenofovir disoproxil, disoproxil Sofosbuvir: ledipasvir/sofosbuvir and (200 mg/245 mg q.d.)1 AUC: ↓ 27% darunavir/ritonavir may Cmax: ↓ 37% increase adverse reactions related to tenofovir disoproxil, GS-3310072: including renal disorders. The AUC: ↔ safety of tenofovir disoproxil Cmax: ↔ when used with Cmin: ↔ ledipasvir/sofosbuvir and a pharmacokinetic enhancer Darunavir: (e.g. ritonavir or cobicistat) AUC: ↔ has not been established. Cmax: ↔ Cmin: ↔ The combination should be used with caution with Ritonavir: frequent renal monitoring, if AUC: ↔ other alternatives are not Cmax: ↔ available (see section 4.4). Cmin: ↑ 48%

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tenofovir (HOS-088083) sofosbuvir (HOS-108928) ledipasvir (HOS-110493) cobicistat (HOS-088111) darunavir (HOS-086181) ritonavir (HOS-084521) emtricitabine (HOS-085840)