Wechselwirkungen · Viread
Viread 245 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 137–138
HOS-110796 · Präparat HOS-093385
137 Medicinal product by Effects on drug levels Recommendation therapeutic areas Mean percent change in AUC, Cmax, concerning (dose in mg) Cmin co-administration with 245 mg tenofovir disoproxil Sofosbuvir/Velpatasvir Sofosbuvir: Increased plasma (400 mg/100 mg q.d.) + AUC: ↓ 29% concentrations of tenofovir Lopinavir/Ritonavir Cmax: ↓ 41% resulting from (800 mg/200 mg q.d.) + co-administration of tenofovir Emtricitabine/Tenofovir GS-3310072: disoproxil, disoproxil AUC: ↔ sofosbuvir/velpatasvir and (200 mg/245 mg q.d.) Cmax: ↔ lopinavir/ritonavir may Cmin: ↔ increase adverse reactions related to tenofovir disoproxil, Velpatasvir: including renal disorders. The AUC: ↔ safety of tenofovir disoproxil Cmax: ↓ 30% when used with Cmin: ↑ 63% sofosbuvir/velpatasvir and a pharmacokinetic enhancer Lopinavir: (e.g. ritonavir or cobicistat) AUC: ↔ has not been established. Cmax: ↔ Cmin: ↔ The combination should be used with caution with Ritonavir: frequent renal monitoring (see AUC: ↔ section 4.4). Cmax: ↔ Cmin: ↔
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tenofovir (HOS-088083) lopinavir (HOS-086269) sofosbuvir (HOS-108928) cobicistat (HOS-088111) velpatasvir (HOS-108929) ritonavir (HOS-084521) emtricitabine (HOS-085840)
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