Wechselwirkungen · Viread
Viread 33 mg/g granules · Abschnitt 4.5 · PDF-Seite 178–179
HOS-110887 · Präparat HOS-093385
178 Medicinal product by Effects on drug levels Recommendation concerning therapeutic areas Mean percent change in AUC, co-administration with 245 mg (dose in mg) Cmax, Cmin tenofovir disoproxil Sofosbuvir/Velpatasvir Sofosbuvir: Increased plasma concentrations (400 mg/100 mg q.d.) + AUC: ↓28% of tenofovir resulting from Darunavir/Ritonavir Cmax: ↓ 38% co-administration of tenofovir (800 mg q.d./100 mg q.d.) + disoproxil, sofosbuvir/velpatasvir Emtricitabine/Tenofovir disoproxil GS-3310072: and darunavir/ritonavir may (200 mg/245 mg q.d.) AUC: ↔ increase adverse reactions related Cmax: ↔ to tenofovir disoproxil, including Cmin: ↔ renal disorders. The safety of tenofovir disoproxil when used Velpatasvir: with sofosbuvir/velpatasvir and a AUC: ↔ pharmacokinetic enhancer (e.g. Cmax: ↓ 24% ritonavir or cobicistat) has not Cmin: ↔ been established.
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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tenofovir (HOS-088083) sofosbuvir (HOS-108928) cobicistat (HOS-088111) velpatasvir (HOS-108929) darunavir (HOS-086181) ritonavir (HOS-084521) emtricitabine (HOS-085840)
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Version 2024-02-29T16:34:00Z · SHA-256 ab427f9266bbb81991653ebf14729e0d885f7cb9014fd47e3b3ee4fc69589ee0 · Passage 22c646a4fca2d85f7d7e8f3db628f4cc568f47de67ec24e4fb95329462c644d3 · Zeichen 21164–22747 im Abschnitt