Wechselwirkungen · Reyataz
REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 16–17
HOS-112089 · Präparat HOS-093615
16 Medicinal products by Interaction Recommendations concerning co- therapeutic area administration Proton pump inhibitors Omeprazole 40 mg once daily Atazanavir (am): 2 hr after omeprazole Co-administration of REYATAZ (atazanavir 400 mg once daily Atazanavir AUC: ↓61% (↓65% ↓55%) with ritonavir and proton pump with ritonavir 100 mg once daily) Atazanavir Cmax: ↓66% (↓62% ↓49%) inhibitors is not recommended. If Atazanavir Cmin: ↓65% (↓71% ↓59%) the combination is judged Omeprazole 20 mg once daily Atazanavir (am): 1 hr after omeprazole unavoidable, close clinical (atazanavir 400 mg once daily Atazanavir AUC: ↓30% (↓43% ↓14%)* monitoring is recommended in with ritonavir 100 mg once daily) Atazanavir Cmax: ↓31% (↓42% ↓17%)* combination with an increase in the Atazanavir Cmin: ↓31% (↓46% ↓12%)* dose of REYATAZ to 400 mg with 100 mg of ritonavir; doses of proton *When compared to atazanavir 300 mg pump inhibitors comparable to once daily with ritonavir 100 mg once omeprazole 20 mg should not be daily. exceeded (see section 4.4).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ritonavir (HOS-084521) omeprazole (HOS-085912)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-06-29T13:00:00Z · SHA-256 ff5481974bd7c752b73fa0c147cf3e96fc892edc735359fa71817833db471beb · Passage b1851bb3613af61c2ae6ffc33e18682bf713eda925506ce47a825ab3a1bc11dd · Zeichen 35861–37451 im Abschnitt