Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Reyataz

REYATAZ 200 mg hard capsules REYATAZ 300 mg hard capsules · Abschnitt 4.5 · PDF-Seite 21–22

HOS-112110 · Präparat HOS-093615

21 Medicinal products by Interaction Recommendations concerning co- therapeutic area administration KINASE INHIBITORS Fostamatinib The mechanism of interaction is CYP3A4 Concomitant use of fostamatinib inhibition by atazanavir and/or ritonavir. with REYATAZ (with or without ritonavir) may increase the plasma concentration of R406, the active metabolite of fostamatinib. Monitor for toxicities of R406 exposure resulting in dose-related adverse events such as hepatotoxicity and neutropenia. Fostamatinib dose reduction may be required. HERBAL PRODUCTS St. John’s wort (Hypericum Concomitant use of St. John's wort with Co-administration of REYATAZ perforatum) REYATAZ may be expected to result in with products containing St. John's significant reduction in plasma levels of wort is contraindicated. atazanavir. This effect may be due to an induction of CYP3A4. There is a risk of loss of therapeutic effect and development of resistance (see section 4.3). HORMONAL CONTRACEPTIVES Ethinyloestradiol 25 μg + Ethinyloestradiol AUC: ↓19% (↓25% If an oral contraceptive is norgestimate ↓13%) administered with (atazanavir 300 mg once daily Ethinyloestradiol Cmax: ↓16% (↓26% ↓5%) REYATAZ/ritonavir, it is with ritonavir 100 mg once daily) Ethinyloestradiol Cmin: ↓37% (↓45% recommended that the oral ↓29%) contraceptive contain at least 30 μg of ethinyloestradiol and that the Norgestimate AUC: ↑85% (↑67% ↑105%) patient be reminded of strict Norgestimate Cmax: ↑68% (↑51% ↑88%) compliance with this contraceptive Norgestimate Cmin: ↑102% (↑77% ↑131%) dosing regimen. Co-administration of REYATAZ/ritonavir with other While the concentration of hormonal contraceptives or oral ethinyloestradiol was increased with contraceptives containing atazanavir given alone, due to both UGT progestogens other than and CYP3A4 inhibition by atazanavir, the norgestimate has not been studied, net effect of atazanavir/ritonavir is a and therefore should be avoided. decrease in ethinyloestradiol levels An alternate reliable method of because of the inducing effect of ritonavir. contraception is recommended.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): norgestimate (HOS-110544) ritonavir (HOS-084521) fostamatinib (HOS-086224)