Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Reyataz

REYATAZ 50 mg oral powder · Abschnitt 4.5 · PDF-Seite 49

HOS-112178 · Präparat HOS-093615

The mechanism of the clarithromycin/atazanavir interaction is CYP3A4 inhibition. ANTIFUNGALS Ketoconazole 200 mg once No significant effect on atazanavir Ketoconazole and itraconazole daily concentrations was observed. should be used cautiously with (atazanavir 400 mg once daily) REYATAZ/ritonavir, high Itraconazole Itraconazole, like ketoconazole, is a strong doses of ketoconazole and inhibitor as well as a substrate of CYP3A4. itraconazole (> 200 mg/day) are not recommended. Based on data obtained with other boosted PIs and ketoconazole, where ketoconazole AUC showed a 3-fold increase, REYATAZ/ritonavir is expected to increase ketoconazole or itraconazole concentrations. Voriconazole 200 mg twice Voriconazole AUC: ↓33% (↓42% ↓22%) Co-administration of daily (atazanavir Voriconazole Cmax: ↓10% (↓22% ↓4%) voriconazole and REYATAZ 300 mg/ritonavir 100 mg once Voriconazole Cmin: ↓39% (↓49% ↓28%) with ritonavir is not daily) recommended unless an Atazanavir AUC: ↓12% (↓18% ↓5%) assessment of the benefit/risk Subjects with at least one Atazanavir Cmax: ↓13% (↓20% ↓4%) to the patient justifies the use functional CYP2C19 allele. Atazanavir Cmin: ↓20% (↓28% ↓10%) of voriconazole (see section 4.4). Ritonavir AUC: ↓12% (↓17% ↓7%) Ritonavir Cmax: ↓9% (↓17% ↔0%) At the time voriconazole Ritonavir Cmin: ↓25% (↓35% ↓14%) treatment is required, a patient's CYP2C19 genotype In the majority of patients with at least one should be performed if functional CYP2C19 allele, a reduction in feasible. both voriconazole and atazanavir exposures are expected. Therefore if the combination is

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): ketoconazole (HOS-084513) voriconazole (HOS-084524) itraconazole (HOS-084516) clarithromycin (HOS-084517) ritonavir (HOS-084521)