Nebenwirkungen · Lysodren
Lysodren 500 mg tablets · Abschnitt 4.8 · PDF-Seite 8
HOS-112504 · Präparat HOS-093689
Paediatric population Neuro-psychological retardation may be observed during mitotane treatment. In such cases, thyroid function should be investigated in order to identify a possible thyroid impairment linked to mitotane treatment. Hypothyroidism and growth retardation may be also observed. One case of encephalopathy has been observed in a paediatric patient five months after initiation of the treatment; this case was considered to be related to an increased mitotane plasma level of 34.5 mg/L. After six months mitotane plasma levels were undetectable and the patient recovered clinically. Oestrogenic-like effects (such as gynaecomastia in male patients and breast development and/or vaginal bleeding in female patients) have been observed.
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Version 2026-03-11T11:11:00Z · SHA-256 8857f8543d9dfcf9df89b956cb88735a9c924712c239c2879d16e7b6e36c86ba · Passage fe74a5988eac343b9b52ae240a65c90d0500c5704e181d5e7ce8d695339c13f7 · Zeichen 7693–8440 im Abschnitt