Wechselwirkungen · Kivexa
Kivexa 600 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-113481 · Präparat HOS-093937
Clinically significant interaction unlikely. Cimetidine eliminated only in part by renal organic cation transport system. CYTOTOXICS Cladribine/Lamivudine Interaction not studied. Therefore, the concomitant use of lamivudine with cladribine In vitro lamivudine inhibits the is not recommended (see intracellular phosphorylation of section 4.4). cladribine leading to a potential risk of cladribine loss of efficacy in case of combination in the clinical setting. Some clinical findings also support a possible interaction between lamivudine and cladribine OPIOIDS Methadone/Abacavir Abacavir: AUC No Kivexa dosage adjustment (40 to 90 mg once daily for 14 Cmax 35% necessary. days/600 mg single dose, then 600 mg twice daily for 14 days) Methadone: CL/F 22% Methadone dosage adjustment unlikely in majority of Methadone/Lamivudine Interaction not studied. patients; occasionally methadone re-titration may be required.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): methadone (HOS-086198) cimetidine (HOS-085835) cladribine (HOS-085842)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-01-19T12:00:00Z · SHA-256 014b022d5230b58f7efa74f9573b1c2e42d28f6a3d171aa8848bc0f8c92c1380 · Passage 3bb42b8e96076847ca3aeb445cb6bf4f6cf7f1f0ef62e5fb0170f713aaf7d90c · Zeichen 6118–7873 im Abschnitt