Nebenwirkungen · Avastin
Avastin 25 mg/ml concentrate for solution for infusion · Abschnitt 4.8 · PDF-Seite 15
HOS-113573 · Präparat HOS-093945
Gastrointestinal perforations have been reported in clinical trials with an incidence of less than 1% in patients with non-squamous non-small cell lung cancer, up to 1.3% in patients with metastatic breast cancer, up to 2.0% in patients with metastatic renal cell cancer or in patients with ovarian cancer, and up to 2.7% (including gastrointestinal fistula and abscess) in patients with metastatic colorectal cancer. From a clinical trial in patients with persistent, recurrent, or metastatic cervical cancer (study GOG- 0240), GI perforations (all grade) were reported in 3.2% of patients, all of whom had a history of prior pelvic radiation.
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Version 2026-01-27T12:02:00Z · SHA-256 66d06bf8e8d4853783377bc4046bd6b4b0e313cc348c230743646f93a9381bb1 · Passage 7afe44755754d12c8713c1374d055ebe869cd01caf459adc03d8ef04c5cc3eb9 · Zeichen 19645–20289 im Abschnitt