Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Omnitrope

Omnitrope 5 mg/1.5 ml solution for injection in cartridge Omnitrope 10 mg/1.5 ml solution for injection in cartridge · Abschnitt 4.5 · PDF-Seite 8

HOS-114163 · Präparat HOS-094049

Data from an interaction study performed in growth hormone deficient adults suggests that somatropin administration may increase the clearance of compounds known to be metabolised by cytochrome P450 isoenzymes. The clearance of compounds metabolised by cytochrome P450 3A4 (e.g. sex steroids, corticosteroids, anticonvulsants and ciclosporin) may be especially increased resulting in lower plasma levels of these compounds. The clinical significance of this is unknown. Also see section 4.4 for statements regarding diabetes mellitus and thyroid disorder and section 4.2 for statement on oral oestrogen replacement therapy.

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