Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Tarceva

Tarceva 25 mg film-coated tablets Tarceva 100 mg film-coated tablets Tarceva 150 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 10

HOS-114501 · Präparat HOS-094097

Infections and infestations Very common infection* Metabolism and nutrition disorders Very common anorexia, weight decreased Psychiatric disorders Very common depression Nervous system disorders Very common neuropathy, headache Eye disorders Very common keratoconjunctivitis sicca Common keratitis, conjunctivitis Uncommon eyelash changes* Very rare corneal perforations, corneal ulcerations, uveitis Respiratory, thoracic and mediastinal disorders Very common dyspnoea, cough Common epistaxis Uncommon interstitial lung disease* Gastrointestinal disorders Very common diarrhoea*, nausea, vomiting, stomatitis, abdominal pain, dyspepsia, flatulence Common gastro-intestinal bleeding* Uncommon gastro-intestinal perforations* Rare pneumatosis intestinalis Hepatobiliary disorders Very common liver function test abnormalities* Rare hepatic failure*, hepatitis Not known (Cannot be acute hepatitis estimated from the available data) Skin and subcutaneous tissue disorders Very common rash*, pruritus Common alopecia, dry skin, paronychia, folliculitis, acne/dermatitis acneiform, skin fissures Uncommon hirsutism, eyebrow changes, brittle and loose nails, mild skin reactions such as hyperpigmentation Rare palmar plantar erythrodysaesthesia syndrome Very rare Stevens-Johnson syndrome/Toxic epidermal necrolysis* Renal and urinary disorders Common renal insufficiency Uncommon nephritis, proteinuria General disorders and administration site conditions Very common fatigue, pyrexia, rigors *For additional details, see section "Description of selected adverse reactions" below.

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