Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Aptivus

Aptivus 250 mg soft capsules · Abschnitt 4.5 · PDF-Seite 19

HOS-114841 · Präparat HOS-094169

Antacids aluminium- and Tipranavir Cmax ↓ 25% Dosing of Aptivus, co- magnesium-based antacid Tipranavir AUC ↓ 27% administered with low dose QD ritonavir, with antacids should be Mechanism unknown separated by at least a two hours time interval. Proton pump inhibitors (PPIs) Omeprazole 40 mg QD Omeprazole Cmax ↓ 73% The combined use of Aptivus, co- Omeprazole AUC ↓ 70% administered with low dose ritonavir, with either omeprazole Similar effects were observed for or esomeprazole is not the S-enantiomer, esomeprazole. recommended (see section 4.4). If unavoidable, upward dose Induction of CYP 2C19 by adjustments for either tipranavir/r omeprazole or esomeprazole may be considered based on clinical Tipranavir ↔ response to therapy. There are no data available indicating that omeprazole or esomeprazole dose adjustments will overcome the observed pharmacokinetic interaction. Recommendations for maximal doses of omeprazole or esomeprazole are found in the corresponding product information. No tipranavir with ritonavir dose adjustment is required. Lansoprazole Based on the metabolic profiles The combined use of Aptivus, co- Pantoprazole of tipranavir/r and the proton administered with low dose Rabeprazole pump inhibitors, an interaction ritonavir, with proton pump No interaction study can be expected. As a result of inhibitors is not recommended performed CYP3A4 inhibition and (see section 4.4). If the co- CYP2C19 induction by administration is judged tipranavir/r, lansoprazole and unavoidable, this should be done pantoprazole plasma under close clinical monitoring. concentrations are difficult to predict. Rabeprazole plasma concentrations might decrease as a result of induction of CYP2C19 by tipranavir/r.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): lansoprazole (HOS-085166) rabeprazole (HOS-114843) esomeprazole (HOS-087944) pantoprazole (HOS-085167) ritonavir (HOS-084521) omeprazole (HOS-085912)