Wechselwirkungen · Revatio
Revatio 20 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 8
HOS-114953 · Präparat HOS-094193
In three specific drug-drug interaction studies, the alpha-blocker doxazosin (4 mg and 8 mg) and sildenafil (25 mg, 50 mg, or 100 mg) were administered simultaneously to patients with benign prostatic hyperplasia (BPH) stabilized on doxazosin therapy. In these study populations, mean additional reductions of supine systolic and diastolic blood pressure of 7/7 mmHg, 9/5 mmHg, and 8/4 mmHg, respectively, and mean additional reductions of standing blood pressure of 6/6 mmHg, 11/4 mmHg, and 4/5 mmHg, respectively were observed. When sildenafil and doxazosin were administered simultaneously to patients stabilized on doxazosin therapy, there were infrequent reports of patients who experienced symptomatic postural hypotension. These reports included dizziness and lightheadedness, but not syncope. Concomitant administration of sildenafil to patients taking alpha-blocker therapy may lead to symptomatic hypotension in susceptible individuals (see section 4.4).
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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): doxazosin (HOS-088800) lead (HOS-085592)
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Version 2026-10-13T14:12:00Z · SHA-256 38afb4f2877b63c9a3d5213ff8cb4458ff9d43618600f9ce01caed1bd5a4764f · Passage 14be1b2f7f9bdf4d88008c516b2997ace4c575593a1757a4a2098a060188e12d · Zeichen 8515–9479 im Abschnitt