Wechselwirkungen · Competact
Competact 15 mg/850 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 7
HOS-115213 · Präparat HOS-094245
Cationic medicinal products that are eliminated by renal tubular secretion (e.g. cimetidine) may interact with metformin by competing for common renal tubular transport systems. A study conducted in seven normal healthy volunteers showed that cimetidine, administered as 400 mg twice daily, increased metformin systemic exposure (AUC) by 50% and Cmax by 81%. Therefore, close monitoring of glycaemic control, dose adjustment within the recommended posology and changes in diabetic treatment should be considered when cationic medicinal products that are eliminated by renal tubular secretion are co-administered.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): cimetidine (HOS-085835)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-04-09T10:33:00Z · SHA-256 3615be1e7bbb8cfa815bb6a83c363e1a5d1ff5a97c3b12dfeb5eb3ed217ec618 · Passage eaefa63c865976428e27f4592671e04a2968f3205ea355277c80cd50f3aeb254 · Zeichen 1113–1725 im Abschnitt