Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Prezista

PREZISTA 100 mg/ml oral suspension · Abschnitt 4.5 · PDF-Seite 23–24

HOS-116425 · Präparat HOS-094447

23 For the treatment of Not studied. Concomitant use of A safe and effective dose of pulmonary arterial sildenafil or tadalafil for the treatment of sildenafil for the treatment of hypertension pulmonary arterial hypertension and pulmonary arterial hypertension Sildenafil boosted PREZISTA may increase plasma co-administered with boosted Tadalafil concentrations of sildenafil or tadalafil. PREZISTA has not been (CYP3A inhibition) established. There is an increased potential for sildenafil-associated adverse events (including visual disturbances, hypotension, prolonged erection and syncope). Therefore, co-administration of boosted PREZISTA and sildenafil when used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3). Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with boosted PREZISTA is not recommended. PROTON PUMP INHIBITORS Omeprazole # Boosted PREZISTA can be darunavir AUC ↔ 20 mg once daily # darunavir Cmin ↔ co-administered with proton pump # darunavir Cmax ↔ inhibitors without dose adjustments. SEDATIVES/HYPNOTICS Buspirone Not studied. Sedative/hypnotics are Clinical monitoring is Clorazepate extensively metabolised by CYP3A. recommended when Diazepam Co-administration with boosted co-administering boosted Estazolam PREZISTA may cause a large increase in PREZISTA with these Flurazepam the concentration of these medicines. sedatives/hypnotics and a lower Midazolam (parenteral) dose of the sedatives/hypnotics Zolpidem should be considered.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tadalafil (HOS-086316) estazolam (HOS-086165) clorazepate (HOS-086164) diazepam (HOS-085904) zolpidem (HOS-086327) buspirone (HOS-086325) sildenafil (HOS-086162) flurazepam (HOS-086166) midazolam (HOS-086167) omeprazole (HOS-085912)