Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Prezista

PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 58

HOS-116520 · Präparat HOS-094447

Clopidogrel Not studied. Co-administration of Co-administration of clopidogrel clopidogrel with boosted PREZISTA is with boosted PREZISTA is not expected to decrease clopidogrel active recommended. Use of other metabolite plasma concentration, which antiplatelets not affected by CYP may reduce the antiplatelet activity of inhibition or induction (e.g. clopidogrel. prasugrel) is recommended. Warfarin Not studied. Warfarin concentrations may It is recommended that the be affected when co-administered with international normalised ratio darunavir with low dose ritonavir. (INR) be monitored when warfarin is combined with PREZISTA co-administered with low dose ritonavir. ANTICONVULSANTS Phenobarbital Not studied. Phenobarbital and phenytoin PREZISTA co-administered with Phenytoin are expected to decrease plasma low dose ritonavir should not be concentrations of darunavir and its used in combination with these pharmacoenhancer. medicines. (induction of CYP450 enzymes) Carbamazepine carbamazepine AUC ↑ 45% No dose adjustment for 200 mg twice daily carbamazepine Cmin ↑ 54% PREZISTA/ritonavir is carbamazepine Cmax ↑ 43% recommended. If there is a need to darunavir AUC ↔ combine PREZISTA/ritonavir and darunavir Cmin ↓ 15% carbamazepine, patients should be darunavir Cmax ↔ monitored for potential carbamazepine-related adverse events. Carbamazepine concentrations should be monitored and its dose should be titrated for adequate response. Based upon the findings, the carbamazepine dose may need to be reduced by 25% to 50% in the presence of PREZISTA/ritonavir. Clonazepam Not studied. Co-administration of Clinical monitoring is boosted PREZISTA with clonazepam recommended when may increase concentrations of co-administering boosted clonazepam. (CYP3A inhibition) PREZISTA with clonazepam.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) carbamazepine (HOS-085618) clonazepam (HOS-116372) clopidogrel (HOS-087927) prasugrel (HOS-112066) ritonavir (HOS-084521) phenytoin (HOS-084531) warfarin (HOS-085950)