Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Prezista

PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 59

HOS-116522 · Präparat HOS-094447

Concomitant use of PREZISTA Clinical monitoring is co-administered with low dose ritonavir recommended when and these antidepressants may increase co-administering PREZISTA with concentrations of the antidepressant. low dose ritonavir with these (CYP2D6 and/or CYP3A inhibition) antidepressants and a dose adjustment of the antidepressant Amitriptyline may be needed. Desipramine Imipramine Nortriptyline Trazodone ANTIEMETICS Domperidone Not studied. Co-administration of domperidone with boosted PREZISTA is contraindicated. ANTIFUNGALS Voriconazole Not studied. Ritonavir may decrease Voriconazole should not be plasma concentrations of voriconazole. combined with PREZISTA (induction of CYP450 enzymes) co-administered with low dose ritonavir unless an assessment of the benefit/risk ratio justifies the use of voriconazole. Fluconazole Not studied. PREZISTA may increase Caution is warranted and clinical Isavuconazole antifungal plasma concentrations and monitoring is recommended. When Itraconazole posaconazole, isavuconazole, co-administration is required the Posaconazole itraconazole, or fluconazole may increase daily dose of itraconazole should darunavir concentrations. not exceed 200 mg. (CYP3A and/or P-gp inhibition)

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): isavuconazole (HOS-085186) nortriptyline (HOS-086245) amitriptyline (HOS-085911) desipramine (HOS-086249) imipramine (HOS-085907) domperidone (HOS-114656) voriconazole (HOS-084524) itraconazole (HOS-084516) trazodone (HOS-086251) fluconazole (HOS-087945) ritonavir (HOS-084521) posaconazole (HOS-085622)