Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Prezista

PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 61–62

HOS-116527 · Präparat HOS-094447

61  Perphenazine Not studied. PREZISTA is expected to A dose decrease may be needed for Risperidone increase these antipsychotic plasma these drugs when co-administered Thioridazine concentrations. with PREZISTA co-administered (CYP3A, CYP2D6 and/or P-gp with low dose ritonavir. inhibition) Lurasidone Concomitant administration of Pimozide PREZISTA with low dose Sertindole ritonavir and lurasidone, pimozide or sertindole is contraindicated (see section 4.3). β-BLOCKERS Carvedilol Not studied. PREZISTA is expected to Clinical monitoring is Metoprolol increase these β-blocker plasma recommended when Timolol concentrations. co-administering PREZISTA with (CYP2D6 inhibition) β-blockers. A lower dose of the β-blocker should be considered. CALCIUM CHANNEL BLOCKERS Amlodipine Not studied. PREZISTA co-administered Clinical monitoring of therapeutic Diltiazem with low dose ritonavir can be expected and adverse effects is Felodipine to increase the plasma concentrations of recommended when these Nicardipine calcium channel blockers. medicines are concomitantly Nifedipine (CYP3A and/or CYP2D6 inhibition) administered with PREZISTA with Verapamil low dose ritonavir. CORTICOSTEROIDS Corticosteroids primarily Fluticasone: in a clinical study where Concomitant use of PREZISTA metabolised by CYP3A ritonavir 100 mg capsules twice daily with low dose ritonavir and (including were co-administered with 50 g corticosteroids (all routes of betamethasone, intranasal fluticasone propionate (4 times administration) that are budesonide, fluticasone, daily) for 7 days in healthy subjects, metabolised by CYP3A may mometasone, prednisone, fluticasone propionate plasma increase the risk of development of triamcinolone) concentrations increased significantly, systemic corticosteroid effects, whereas the intrinsic cortisol levels including Cushing’s syndrome and decreased by approximately 86% (90% adrenal suppression. CI 82-89%). Greater effects may be expected when fluticasone is inhaled. Co-administration with CYP3A- Systemic corticosteroid effects including metabolised corticosteroids is not Cushing’s syndrome and adrenal recommended unless the potential suppression have been reported in benefit to the patient outweighs the patients receiving ritonavir and inhaled or risk, in which case patients should intranasally administered fluticasone. The be monitored for systemic effects of high fluticasone systemic corticosteroid effects. exposure on ritonavir plasma levels are unknown. Alternative corticosteroids which are less dependent on CYP3A Other corticosteroids: interaction not metabolism e.g. beclomethasone studied. Plasma concentrations of these should be considered, particularly medicinal products may be increased for long term use. when co-administered with PREZISTA with low dose ritonavir, resulting in reduced serum cortisol concentrations. Dexamethasone Not studied. Dexamethasone may Systemic dexamethasone should (systemic) decrease plasma concentrations of be used with caution when darunavir. combined with PREZISTA (CYP3A induction) co-administered with low dose ritonavir.

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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): sertindole (HOS-085601) diltiazem (HOS-086288) triamcinolone (HOS-086333) nifedipine (HOS-086289) fluticasone (HOS-108914) nicardipine (HOS-090619) felodipine (HOS-108908) fluticasone propionate (HOS-086331) carvedilol (HOS-115322) risperidone (HOS-086280) amlodipine (HOS-086287) thioridazine (HOS-086281) perphenazine (HOS-116395) calcium (HOS-085615) betamethasone (HOS-090066) dexamethasone (HOS-084535) budesonide (HOS-086332) pimozide (HOS-085600) mometasone (HOS-114048) ritonavir (HOS-084521) beclomethasone (HOS-086334) lurasidone (HOS-086148) prednisone (HOS-084526) metoprolol (HOS-090094) timolol (HOS-090571) verapamil (HOS-090602)