Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Prezista

PREZISTA 75 mg film-coated tablets PREZISTA 150 mg film-coated tablets PREZISTA 600 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 65–66

HOS-116532 · Präparat HOS-094447

65 For the treatment of Not studied. Concomitant use of A safe and effective dose of pulmonary arterial sildenafil or tadalafil for the treatment of sildenafil for the treatment of hypertension pulmonary arterial hypertension and pulmonary arterial hypertension Sildenafil darunavir co-administered with low dose co-administered with PREZISTA Tadalafil ritonavir may increase plasma and low dose ritonavir has not concentrations of sildenafil or tadalafil. been established. There is an (CYP3A inhibition) increased potential for sildenafil-associated adverse events (including visual disturbances, hypotension, prolonged erection and syncope). Therefore, co-administration of PREZISTA with low dose ritonavir and sildenafil when used for the treatment of pulmonary arterial hypertension is contraindicated (see section 4.3). Co-administration of tadalafil for the treatment of pulmonary arterial hypertension with PREZISTA and low dose ritonavir is not recommended. PROTON PUMP INHIBITORS Omeprazole # PREZISTA co-administered with darunavir AUC ↔ 20 mg once daily # darunavir Cmin ↔ low dose ritonavir can be # darunavir Cmax ↔ co-administered with proton pump inhibitors without dose adjustments. SEDATIVES/HYPNOTICS Buspirone Not studied. Sedative/hypnotics are Clinical monitoring is Clorazepate extensively metabolised by CYP3A. recommended when Diazepam Co-administration with co-administering PREZISTA with Estazolam PREZISTA/ritonavir may cause a large these sedatives/hypnotics and a Flurazepam increase in the concentration of these lower dose of the Midazolam (parenteral) medicines. sedatives/hypnotics should be Zolpidem considered.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): tadalafil (HOS-086316) estazolam (HOS-086165) clorazepate (HOS-086164) diazepam (HOS-085904) zolpidem (HOS-086327) buspirone (HOS-086325) sildenafil (HOS-086162) ritonavir (HOS-084521) flurazepam (HOS-086166) midazolam (HOS-086167) omeprazole (HOS-085912)