Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Advagraf

Advagraf 0.5 mg prolonged-release hard capsules Advagraf 1 mg prolonged-release hard capsules Advagraf 3 mg prolonged-release hard capsules Advagraf 5 mg prolonged-release hard capsules · Abschnitt 4.5 · PDF-Seite 10

HOS-116792 · Präparat HOS-094481

Medicinal products which have effects on tacrolimus Drug/Substance Class or Drug interaction effect Recommendations concerning Name co-administration Grapefruit or grapefruit juice May increase tacrolimus whole Avoid grapefruit or grapefruit blood trough concentrations and juice. increase the risk of serious adverse reactions (e.g., neurotoxicity, QT prolongation) [see section 4.4]. Ciclosporin May increase tacrolimus whole The simultaneous use of blood trough concentrations. In ciclosporin and tacrolimus addition, synergistic/additive should be avoided [see nephrotoxic effects can occur. section 4.4]. Products known to have May enhance nephrotoxic or Concurrent use of tacrolimus nephrotoxic or neurotoxic neurotoxic effects of tacrolimus. with drugs known to have effects: nephrotoxic effects should be aminoglycosides, gyrase avoided. When co- inhibitors, vancomycin, administration cannot be sulfamethoxazole + avoided, monitor renal trimethoprim, NSAIDs, function and other side effects ganciclovir, acyclovir, and adjust tacrolimus dose if amphotericin B, ibuprofen, needed. cidofovir, foscarnet

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): foscarnet (HOS-110484) sulfamethoxazole (HOS-084533) ibuprofen (HOS-087884) amphotericin B (HOS-109312) trimethoprim (HOS-085184) cidofovir (HOS-110482) grapefruit juice (HOS-088787) vancomycin (HOS-110486) ganciclovir (HOS-085194) acyclovir (HOS-088527)