Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Advagraf

Advagraf 0.5 mg prolonged-release hard capsules Advagraf 1 mg prolonged-release hard capsules Advagraf 3 mg prolonged-release hard capsules Advagraf 5 mg prolonged-release hard capsules · Abschnitt 4.5 · PDF-Seite 12–13

HOS-116835 · Präparat HOS-094481

12  Drug/Substance Class or Drug interaction effect Recommendations concerning Name co-administration Products known to have high Tacrolimus is extensively bound to Monitor tacrolimus whole affinity for plasma proteins, plasma proteins. Possible blood trough concentrations e.g.: NSAIDs, oral interactions with other active and adjust tacrolimus dose if anticoagulants, oral substances known to have high needed [see section 4.2]. antidiabetics affinity for plasma proteins should be considered. Prokinetic agents: May increase tacrolimus whole Monitor tacrolimus whole metoclopramide, cimetidine blood trough concentrations and blood trough concentrations and magnesium-aluminium- increase the risk of serious adverse and reduce tacrolimus dose if hydroxide reactions (e.g., neurotoxicity, QT needed [see section 4.2]. prolongation). Monitor closely for renal function, for QT prolongation with ECG, and for other side effects. Maintenance doses of May decrease tacrolimus whole Monitor tacrolimus whole corticosteroids blood trough concentrations and blood trough concentrations increase the risk of rejection [see and increase tacrolimus dose if section 4.4]. needed [see section 4.2]. Monitor graft function closely. High dose prednisolone or May have impact on tacrolimus Monitor tacrolimus whole methylprednisolone blood levels (increase or decrease) blood trough concentrations when administered for the treatment and adjust tacrolimus dose if of acute rejection. needed.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): prednisolone (HOS-086337) cimetidine (HOS-085835) methylprednisolone (HOS-088374) metoclopramide (HOS-090626)