Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Abraxane

Abraxane 5 mg/ml powder for dispersion for infusion. · Abschnitt 4.8 · PDF-Seite 10–11

HOS-117874 · Präparat HOS-094711

10  Monotherapy (N = 789) Combination therapy Combination therapy with gemcitabine with carboplatin (N = 421) (N = 514) Blood and lymphatic system disorders Bone marrow suppression, neutropenia, Neutropenia, Neutropenia3, Very thrombocytopenia, anaemia, leukopenia, thrombocytopenia, thrombocytopenia3, common: lymphopenia anaemia anaemia3, leukopenia3 Febrile neutropenia Pancytopenia Febrile neutropenia, Common: lymphopenia Thrombotic Pancytopenia Uncommon: thrombocytopenic purpura Rare: Pancytopenia Immune system disorders Drug hypersensitivity, Uncommon: Hypersensitivity hypersensitivity Rare: Severe hypersensitivity1 Metabolism and nutrition disorders Very Anorexia Dehydration, decreased Decreased appetite common: appetite, hypokalaemia Dehydration, decreased appetite, Dehydration Common: hypokalaemia Hypophosphataemia, fluid retention, hypoalbuminaemia, polydipsia, Uncommon: hyperglycaemia, hypocalcaemia, hypoglycaemia, hyponatraemia Not known: Tumour lysis syndrome1 Psychiatric disorders Very Depression, insomnia common: Common: Depression, insomnia, anxiety Anxiety Insomnia Uncommon: Restlessness Nervous system disorders Peripheral neuropathy, neuropathy, Peripheral neuropathy, Peripheral neuropathy Very hypoaesthesia, paraesthesia dizziness, headache, common: dysgeusia Peripheral sensory neuropathy, Dizziness, headache, dizziness, peripheral motor neuropathy, dysgeusia Common: ataxia, headache, sensory disturbance, somnolence, dysgeusia Polyneuropathy, areflexia, syncope, VIIth nerve paralysis postural dizziness, dyskinesia, Uncommon: hyporeflexia, neuralgia, neuropathic pain, tremor, sensory loss Not known: Cranial nerve palsies multiple 1 Eye disorders Vision blurred, lacrimation increased, Lacrimation increased Vision blurred Common: dry eye, keratoconjunctivitis sicca, madarosis Reduced visual acuity, abnormal vision, Cystoid macular oedema Uncommon: eye irritation, eye pain, conjunctivitis, visual disturbance, eye pruritus, keratitis Rare: Cystoid macular oedema1

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