Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Celsentri

CELSENTRI 20 mg/mL oral solution · Abschnitt 4.5 · PDF-Seite 39–40

HOS-118510 · Präparat HOS-094825

The effect of maraviroc on digoxin at the dose of 600 mg BID has not been studied. ORAL CONTRACEPTIVES Ethinylestradiol 30 mcg QD Ethinylestradiol. AUCt: ↔ 1.00 CELSENTRI 300 mg twice (maraviroc 100 mg BID) Ethinylestradiol. Cmax: ↔ 0.99 daily. and ethinylestradiol can Maraviroc concentrations not be co-administered without measured, no interaction expected. dose adjustment. Levonorgestrel 150 mcg Levonorgestrel. AUC12: ↔ 0.98 CELSENTRI 300 mg twice QD Levonorgestrel. Cmax: ↔ 1.01 daily and levonorgestrel can (maraviroc 100 mg BID) Maraviroc concentrations not be co-administered without measured, no interaction expected. dose adjustment. SEDATIVES Benzodiazepines Midazolam 7.5 mg Single Midazolam. AUC: ↔ 1.18 CELSENTRI 300 mg twice Dose Midazolam. Cmax: ↔ 1.21 daily and midazolam can be (maraviroc 300 mg BID) Maraviroc concentrations not co-administered without dose measured, no interaction expected. adjustment. 39  HERBAL PRODUCTS St. John’s Wort Co-administration of maraviroc with Concomitant use of maraviroc (Hypericum Perforatum) St. John's Wort is expected to and St. John's Wort or substantially decrease maraviroc products containing St. John's concentrations and may result in Wort is not recommended. suboptimal levels and lead to loss of virologic response and possible resistance to maraviroc. a Refer to Table 1 for maraviroc paediatric dosing recommendations when co-administered with antiretroviral therapy and other

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RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): levonorgestrel (HOS-089677) digoxin (HOS-086172) lead (HOS-085592) midazolam (HOS-086167)