Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Copalia HCT

Copalia HCT 5 mg/160 mg/12.5 mg film-coated tablets Copalia HCT 10 mg/160 mg/12.5 mg film-coated tablets Copalia HCT 5 mg/160 mg/25 mg film-coated tablets Copalia HCT 10 mg/160 mg/25 mg film-coated tablets Copalia HCT 10 mg/320 mg/25 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9

HOS-122662 · Präparat HOS-095555

Copalia Known interactions Effect of the interaction with other medicinal products HCT with the following individual agents component Amlodipine CYP3A4 inhibitors Concomitant use of amlodipine with strong or moderate (i.e. ketoconazole, CYP3A4 inhibitors (protease inhibitors, azole antifungals, itraconazole, ritonavir) macrolides like erythromycin or clarithromycin, verapamil or diltiazem) may give rise to significant increase in amlodipine exposure. The clinical translation of these pharmacokinetic variations may be more pronounced in the elderly. Clinical monitoring and dose adjustment may thus be required. CYP3A4 inducers Upon co-administration of known inducers of the (anticonvulsant agents CYP3A4, the plasma concentration of amlodipine may [e.g. carbamazepine, vary. Therefore, blood pressure should be monitored and phenobarbital, dose regulation considered both during and after phenytoin, concomitant medication particularly with strong CYP3A4 fosphenytoin, inducers (e.g. rifampicin, hypericum perforatum). primidone], rifampicin, Hypericum perforatum [St. John’s wort]) Simvastatin Co-administration of multiple doses of 10 mg amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared to simvastatin alone. It is recommended to limit the dose of simvastatin to 20 mg daily in patients on amlodipine.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): fosphenytoin (HOS-110222) diltiazem (HOS-086288) protease (HOS-085623) phenobarbital (HOS-085617) ketoconazole (HOS-084513) carbamazepine (HOS-085618) simvastatin (HOS-086158) itraconazole (HOS-084516) clarithromycin (HOS-084517) erythromycin (HOS-084514) ritonavir (HOS-084521) phenytoin (HOS-084531) primidone (HOS-090551) verapamil (HOS-090602)