Nebenwirkungen · Brilique
Brilique 60 mg film-coated tablets · Abschnitt 4.8 · PDF-Seite 12
HOS-123560 · Präparat HOS-095701
Ticagrelor 60 mg twice ASA alone daily + ASA N=6996 N=6958 Hazard Ratio Safety Endpoints KM% KM% p-value (95% CI) TIMI-defined bleeding categories 2.3 2.32 1.1 <0.0001 TIMI Major (1.68, 3.21) 0.3 1.00 0.3 1.0000 Fatal (0.44, 2.27) 0.6 1.33 0.5 0.3130 ICH (0.77, 2.31) 1.6 3.61 0.5 <0.0001 Other TIMI Major (2.31, 5.65) 3.4 2.54 1.4 <0.0001 TIMI Major or Minor (1.93, 3.35) TIMI Major or Minor or Requiring 16.6 2.64 7.0 <0.0001 medical attention (2.35, 2.97) PLATO-defined bleeding categories 3.5 2.57 1.4 <0.0001 PLATO Major (1.95, 3.37) 2.4 2.38 1.1 <0.0001 Fatal/Life-threatening (1.73, 3.26) 1.1 3.37 0.3 <0.0001 Other PLATO Major (1.95, 5.83) 15.2 2.71 6.2 <0.0001 PLATO Major or Minor (2.40, 3.08) Bleeding category definitions: TIMI Major: Fatal bleeding, OR any intracranial bleeding, OR clinically overt signs of haemorrhage associated with a drop in haemoglobin (Hgb) of ≥50 g/L, or when Hgb is not available, a fall in haematocrit (Hct) of 15%. Fatal: A bleeding event that directly led to death within 7 days. ICH: Intracranial haemorrhage. Other TIMI Major: Non-fatal non-ICH TIMI Major bleeding. TIMI Minor: Clinically apparent with 30-50 g/L decrease in haemoglobin.
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Version 2026-08-18T10:59:00Z · SHA-256 f815638059a70571d33a6ddc4107523f2ae567aafc2b20551ad4a9b0fb2f2aca · Passage 3e610849cb1c1518bf68a35d9434769a04e65325583e64dadd369518a81c8073 · Zeichen 10631–13825 im Abschnitt