Wechselwirkungen · Incresync
Incresync 12.5 mg/30 mg film-coated tablets Incresync 25 mg/30 mg film-coated tablets Incresync 25 mg/45 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 9
HOS-124690 · Präparat HOS-095913
In vitro studies suggest that alogliptin does not inhibit nor induce CYP 450 isoforms at concentrations achieved with the recommended dose of 25 mg alogliptin (see section 5.2). Interaction with substrates of CYP 450 isoforms are thus not expected and have not been shown. In studies in vitro, alogliptin was found to be neither a substrate nor an inhibitor of key transporters associated with disposition of the active substance in the kidney: organic anion transporter-1, organic anion transporter-3 or organic cationic transporter-2 (OCT2). Furthermore, clinical data do not suggest interaction with p-glycoprotein inhibitors or substrates.
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Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2022-09-09T12:31:00Z · SHA-256 cbd1851f0d7bf897be948ef8b74484626964929eb5e4c45499b1be3f0ce7ae66 · Passage 9176aab69efae73df43d85f6f23ecaca000fe0437b9c6b7b18242042afefeefe · Zeichen 2726–3369 im Abschnitt