Wechselwirkungen · Capecitabine Accord
Capecitabine Accord 150 mg film-coated tablets Capecitabine Accord 300 mg film-coated tablets Capecitabine Accord 500 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 11
HOS-125505 · Präparat HOS-096081
Folinic acid/folic acid A combination study with capecitabine and folinic acid indicated that folinic acid has no major effect on the pharmacokinetics of capecitabine and its metabolites. However, folinic acid has an effect on the pharmacodynamics of capecitabine and its toxicity may be enhanced by folinic acid: the maximum tolerated dose (MTD) of capecitabine alone using the intermittent regimen is 3000 mg/m2 per day whereas it is only 2000 mg/m2 per day when capecitabine was combined with folinic acid (30 mg orally bid). The enhanced toxicity may be relevant when switching from 5-FU/LV to a capecitabine regimen. This may also be relevant with folic acid supplementation for folate deficiency due to the similarity between folinic acid and folic acid.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): folic acid (HOS-091424) folate (HOS-091426)
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Version 2025-05-05T15:07:00Z · SHA-256 31136a37a67bcc7d3d37a3db0a926c5402c9346bcaefe911a69ae0fa32bf9225 · Passage 433d77d65cefbe27625c07f7ff658894188a441f7089970d82fb2923ac79ccdf · Zeichen 2427–3187 im Abschnitt