Wirkstoffe & Arzneimittelsicherheit

Nebenwirkungen · Jakavi

Jakavi 5 mg tablets Jakavi 10 mg tablets Jakavi 15 mg tablets Jakavi 20 mg tablets · Abschnitt 4.8 · PDF-Seite 17

HOS-126155 · Präparat HOS-096217

Acute GvHD Chronic Chronic GvHD Acute GvHD (Paediatric GvHD (Paediatric (REACH2) pool) (REACH3) pool) Frequency Frequency Frequency Frequency Adverse drug reaction category category category category Infections and infestations CMV infections Very common Very common Common Common CTCAE3 grade ≥3 Very common Common Common N/A5 Sepsis Very common Common -6 -6 CTCAE grade ≥34 Very common Common -6 -6 Urinary tract infections Very common Common Common Common CTCAE grade ≥3 Common Common Common Common BK virus infections -6 -6 Common Common CTCAE grade ≥3 -6 -6 Uncommon N/A5 Blood and lymphatic system disorders Thrombocytopenia1 Very common Very common Very common Very common CTCAE grade 3 Very common Very common Common Common CTCAE grade 4 Very common Very common Very common Very common 1 Anaemia Very common Very common Very common Very common CTCAE grade 3 Very common Very common Very common Very common Neutropenia1 Very common Very common Very common Very common CTCAE grade 3 Very common Very common Common Very common CTCAE grade 4 Very common Very common Common Very common Pancytopenia1,2 Very common Very common -6 -6 Metabolism and nutrition disorders Hypercholesterolaemia1 Very common Very common Very common Very common CTCAE grade 3 Common N/A5 Common Common CTCAE grade 4 Common N/A5 Uncommon Common Weight gain -6 -6 Common Common CTCAE grade ≥3 -6 -6 N/A5 Common Nervous system disorders Headache Common Common Very common Very common CTCAE grade ≥3 Uncommon N/A5 Common Common Vascular disorders Hypertension Very common Very common Very common Very common CTCAE grade ≥3 Common Very common Common Common Gastrointestinal disorders Increased lipase1 -6 -6 Very common Very common CTCAE grade 3 -6 -6 Common Common CTCAE grade 4 -6 -6 Uncommon Common 1 Increased amylase -6 -6 Very common Very common CTCAE grade 3 -6 -6 Common Common CTCAE grade 4 -6 -6 Common N/A5 Nausea Very common Common -6 -6 CTCAE grade ≥3 Uncommon N/A5 -6 -6 Constipation -6 -6 Common Common CTCAE grade ≥3 -6 -6 N/A5 N/A5

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