Nebenwirkungen · Jakavi
Jakavi 5 mg/ml oral solution · Abschnitt 4.8 · PDF-Seite 49
HOS-126241 · Präparat HOS-096217
In the comparative period of the phase 3 chronic GvHD study (REACH3), new or worsened lipase values were reported in 32.1% of patients in the ruxolitinib arm compared to 23.5% in the BAT arm; corresponding grade 3 (10.6% vs 6.2%) and grade 4 (0.6% vs 0%) increases were similar. During extended follow-up of patients treated with ruxolitinib, increased lipase values were reported in 35.9% of patients; grade 3 and 4 were observed in 9.5% and 0.4% of patients, respectively. Elevated lipase was reported with lower frequency (20.4%, grade 3 and 4: 3.8% and 1.9%, respectively) in paediatric patients.
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Version 2025-11-10T13:51:00Z · SHA-256 f5e9d15f087df0766ff15826906abe609cecf3c8ef177236024d00e93ae36c17 · Passage 75d37fa36225a3922201c55c75a54f097454f732ebe1475dcabbfe112d918188 · Zeichen 19685–20285 im Abschnitt