Wechselwirkungen · Kalydeco
Kalydeco 75 mg film-coated tablets Kalydeco 150 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 12
HOS-126442 · Präparat HOS-096263
Co-administration with digoxin, a sensitive P-gp substrate, increased digoxin exposure by 1.3-fold, consistent with weak inhibition of P-gp by ivacaftor. Administration of ivacaftor may increase systemic exposure of medicinal products that are sensitive substrates of P-gp, which may increase or prolong their therapeutic effect and adverse reactions. When used concomitantly with digoxin or other substrates of P-gp with a narrow therapeutic index, such as ciclosporin, everolimus, sirolimus or tacrolimus, caution and appropriate monitoring should be used.
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): digoxin (HOS-086172) tacrolimus (HOS-085202) everolimus (HOS-086310) sirolimus (HOS-085172)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2025-07-02T15:40:00Z · SHA-256 3213de37cc075be5d4409b79807f1ec8017896be60e7edb796dfbe660a1e4b9f · Passage d9e37bf8f0fc378c7bad828d45dd7c9b35c8585098f91724aa8f08ee63aa4672 · Zeichen 3283–3841 im Abschnitt