Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Cholib

Cholib 145 mg/40 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 32

HOS-127062 · Präparat HOS-096355

Interacting substances Prescribing recommendations Potent CYP 3A4 inhibitors: Itraconazole Ketoconazole Fluconazole Posaconazole Erythromycin Contraindicated with Cholib Clarithromycin Telithromycin HIV protease inhibitors (e.g. nelfinavir) Nefazodone Cobicistat Danazol Contraindicated with Cholib Ciclosporin Gemfibrozil, Other statins and fibrates Contraindicated with Cholib Amiodarone Verapamil Contraindicated with Cholib 145 mg/40 mg Diltiazem Amlodipine Elbasvir Contraindicated with Cholib 145 mg/40 mg Grazoprevir Glecaprevir Contraindicated with Cholib Pibrentasvir Avoid with Cholib unless clinical benefit outweigh the risk Niacin (nicotinic acid) ≥ 1 g/day Monitor patients for any signs and symptoms of muscle pain, tenderness or weakness Patients should be closely monitored. Fusidic acid Temporary suspension of Cholib treatment may be considered Grapefruit juice Avoid when taking Cholib Adjust the dose of these oral anticoagulants Vitamin K antagonists according to INR monitoring Monitor HDL-C and stop either therapy Glitazones (glitazone or Cholib) if HDL-C is too low

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): diltiazem (HOS-086288) nefazodone (HOS-084519) elbasvir (HOS-108814) nelfinavir (HOS-084520) protease (HOS-085623) fusidic acid (HOS-086146) ketoconazole (HOS-084513) pibrentasvir (HOS-086298) cobicistat (HOS-088111) vitamin K (HOS-091176) amlodipine (HOS-086287) gemfibrozil (HOS-088403) glecaprevir (HOS-086297) grapefruit juice (HOS-088787) niacin (HOS-126975) telithromycin (HOS-084523) grazoprevir (HOS-108815) itraconazole (HOS-084516) danazol (HOS-085473) fluconazole (HOS-087945) clarithromycin (HOS-084517) erythromycin (HOS-084514) amiodarone (HOS-085596) posaconazole (HOS-085622) verapamil (HOS-090602)