Wechselwirkungen · Spedra
Spedra 100 mg tablets · Abschnitt 4.5 · PDF-Seite 18
HOS-127459 · Präparat HOS-096405
Potential for pharmacodynamic interactions with avanafil Nitrates Avanafil was shown to augment the hypotensive effects of nitrates compared to placebo in healthy subjects. This is thought to result from the combined effects of nitrates and avanafil on the nitric oxide/cGMP pathway. Therefore, administration of avanafil to patients who are using any form of organic nitrate or nitric oxide donor (such as amyl nitrite) is contraindicated. In a patient who has taken avanafil within 12 hours, where nitrate administration is deemed medically necessary in a life- threatening situation, the likelihood of a significant and potentially dangerous drop in blood pressure is increased. In such circumstances, nitrates should still only be administered under close medical supervision with appropriate haemodynamic monitoring (see section 4.3).
Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.
RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): placebo (HOS-088378) nitric oxide (HOS-088773) amyl nitrite (HOS-088775)
Vollständigen Kontext in der EMA-Fachinformation lesen →Quellennachweis
Version 2026-08-07T15:55:00Z · SHA-256 9f3a1264ef001d577393feb260b99952ed079148f452f8976f0be132f469d380 · Passage fe2c9ba53727b0b06a2032587a11656b20757d24d62f9f08f960060080fc724e · Zeichen 0–839 im Abschnitt