Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Cresemba

CRESEMBA 200 mg powder for concentrate for solution for infusion · Abschnitt 4.5 · PDF-Seite 11–12

HOS-128927 · Präparat HOS-096645

11 Digoxin Digoxin: No isavuconazole dose (P-gp substrate) AUCinf: ↑ 25% adjustment necessary. Cmax: ↑ 33% Digoxin: serum digoxin concentrations should be (P-gp inhibition) monitored and used for titration of the digoxin dose. Oral contraceptives Ethinyl oestradiol and Ethinyl oestradiol No isavuconazole dose norethindrone AUCinf: ↑ 8% adjustment necessary. (CYP3A4/5 substrates) Cmax: ↑ 14% Ethinyl oestradiol and Norethindrone norethindrone: no dose AUCinf: ↑ 16% adjustment required. Cmax: ↑ 6% Antitussives Dextromethorphan Dextromethorphan: No isavuconazole dose (CYP2D6 substrate) AUCinf: ↑ 18% adjustment necessary. Cmax: ↑ 17% Dextromethorphan: no dose Dextrorphan (active metabolite): adjustment required. AUCinf: ↑ 4% Cmax: ↓ 2% Benzodiazepines Midazolam Oral midazolam: No isavuconazole dose (CYP3A4/5 substrate) AUCinf: ↑ 103% adjustment necessary. Cmax: ↑ 72% Midazolam: careful monitoring of clinical signs and symptoms (CYP3A4 inhibition) recommended, and dose reduction if required. Antigout agent Colchicine Not studied. No isavuconazole dose (P-gp substrate) Colchicine concentrations may adjustment necessary. increase. Colchicine has a narrow therapeutic index and should be (P-gp inhibition) monitored, dose reduction if required. Natural products Caffeine Caffeine: No isavuconazole dose (CYP1A2 substrate) AUCinf: ↑ 4% adjustment necessary. Cmax: ↓ 1% Caffeine: no dose adjustment required. Smoking cessation aids Bupropion Bupropion: No isavuconazole dose (CYP2B6 substrate) AUCinf: ↓ 42% adjustment necessary. Cmax: ↓ 31% Bupropion: dose increase if required. (CYP2B6 induction) NNRTI, non-nucleoside reverse-transcriptase inhibitor; P-gp, P-glycoprotein. a) % decrease of the mean trough level values b) Indinavir was only studied after a single dose of 400 mg isavuconazole. AUCinf = area under the plasma concentration-time profiles extrapolated to infinity; AUCtau = area under the plasma concentration-time profiles during the 24 h interval at steady state; Cmax = peak plasma concentration; Cmin,ss = trough levels at steady state.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): indinavir (HOS-084518) bupropion (HOS-086329) digoxin (HOS-086172) caffeine (HOS-085902) colchicine (HOS-086147) norethindrone (HOS-088136) dextromethorphan (HOS-109265) midazolam (HOS-086167)