Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Triumeq

Triumeq 50 mg/600 mg/300 mg film-coated tablets · Abschnitt 4.5 · PDF-Seite 11–12

HOS-129263 · Präparat HOS-096703

11 Antimycobacterials Rifampicin/Dolutegravir Dolutegravir ↓ The dose of dolutegravir is 50 mg twice AUC ↓ 54% daily when co-administered with Cmax ↓ 43% rifampicin. As Triumeq is a fixed dose Cτ ↓ 72% tablet, an additional 50 mg tablet of (induction of UGT1A1 dolutegravir should be administered, and CYP3A enzymes) approximately 12 hours after Triumeq for the duration of the rifampicin co- administration (a separate preparation of dolutegravir is available for this dose adjustment, see section 4.2). Rifabutin Dolutegravir ↔ No dose adjustment is necessary. AUC ↓ 5% Cmax ↑ 16% Cτ ↓ 30% (induction of UGT1A1 and CYP3A enzymes) Anticonvulsants Carbamazepine/Dolutegravir Dolutegravir ↓ The recommended dose of dolutegravir AUC ↓ 49% is 50 mg twice daily when co- Cmax ↓ 33% administered with carbamazepine. As Cτ ↓ 73% Triumeq is a fixed dose tablet, an additional 50 mg tablet of dolutegravir should be administered, approximately 12 hours after Triumeq for the duration of the carbamazepine co-administration (a separate preparation of dolutegravir is available for this dose adjustment, see section 4.2). Phenobarbital/Dolutegravir Dolutegravir↓ The recommended dose of dolutegravir Phenytoin/Dolutegravir (Not studied, decrease is 50 mg twice daily when co- Oxcarbazepine/Dolutegravir expected due to induction administered with these metabolic of UGT1A1 and CYP3A inducers. As Triumeq is a fixed dose enzymes, a similar tablet, an additional 50 mg tablet of reduction in exposure as dolutegravir should be administered, observed with approximately 12 hours after Triumeq carbamazepine is for the duration of the co-administration expected) with these metabolic inducers (a separate preparation of dolutegravir is available for this dose adjustment, see section 4.2). Antihistamines (histamine H2 receptor antagonists) Ranitidine Interaction not studied. No dose adjustment necessary.

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) carbamazepine (HOS-085618) rifabutin (HOS-086262) histamine (HOS-088516) ranitidine (HOS-085660) oxcarbazepine (HOS-110224) phenytoin (HOS-084531)