Wirkstoffe & Arzneimittelsicherheit

Wechselwirkungen · Sovaldi

Sovaldi 150 mg coated granules in sachet Sovaldi 200 mg coated granules in sachet · Abschnitt 4.5 · PDF-Seite 40

HOS-129846 · Präparat HOS-096803

Medicinal product by Effects on drug levels. Recommendation concerning co-administration therapeutic areas Mean ratio (90% with Sovaldi confidence interval) for AUC, Cmax, Cmina,b ANALEPTICS Modafinil Interaction not studied. Co-administration of Sovaldi with modafinil is Expected: expected to decrease the concentration of ↓ Sofosbuvir sofosbuvir, leading to reduced therapeutic effect of ↔ GS-331007 Sovaldi. Such co-administration is not recommended. (Induction of P-gp) ANTIARRHYTHMICS Amiodarone Effect on amiodarone and Coadministration of amiodarone with a sofosbuvir- sofosbuvir concentrations containing regimen may result in serious unknown. symptomatic bradycardia. Use only if no other alternative is available. Close monitoring is recommended if this medicinal product is administered with Sovaldi (see sections 4.4 and 4.8). ANTICOAGULANTS Vitamin K antagonists Interaction not studied Close monitoring of INR is recommended with all vitamin K antagonists. This is due to liver function changes during treatment with Sovaldi. ANTICONVULSANTS Phenobarbital Interaction not studied. Sovaldi is contraindicated with phenobarbital and Phenytoin Expected: phenytoin (see section 4.3). ↓ Sofosbuvir ↔ GS-331007

Originalpassage; keine automatisch abgeleitete Schwere, Häufigkeit oder Kausalität. Auch verneinte Befunde und nicht untersuchte Kombinationen bleiben sichtbar.

RxNorm-Namen im Text (wörtliche Treffer, Rolle nicht bewertet): phenobarbital (HOS-085617) modafinil (HOS-090546) vitamin K (HOS-091176) amiodarone (HOS-085596) phenytoin (HOS-084531)